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Selective immunolesioning of the basal forebrain cholinergic system disrupts short-term memory in rats.
Leanza G, Muir J, Nilsson OG, Wiley RG, Dunnett SB, Bjorklund A (1996) Selective immunolesioning of the basal forebrain cholinergic system disrupts short-term memory in rats. Eur J Neurosci 8:1535-1544. doi: 10.1111/j.1460-9568.1996.tb01616.x
Related Products: 192-IgG-SAP (Cat. #IT-01)
Effects of intraventricular transplantation of NGF-secreting cells on cholinergic basal forebrain neurons after partial immunolesion.
Rossner S, Yu J, Pizzo D, Werrbach-Perez K, Scliebs R, Bigl V, Perez-Polo JR (1996) Effects of intraventricular transplantation of NGF-secreting cells on cholinergic basal forebrain neurons after partial immunolesion. J Neurosci Res 45:40-56. doi: 10.1002/(SICI)1097-4547(19960701)45:1<40::AID-JNR4>3.0.CO;2-H
Related Products: 192-IgG-SAP (Cat. #IT-01)
192-IgG-saporin immunotoxin and ibotenic acid lesions of nucleus basalis and medial septum produce comparable deficits on delayed nonmatching-to-sample performance in rats.
Robinson JK, Wiley RG, Wenk GL, Lappi DA, Crawley JN (1996) 192-IgG-saporin immunotoxin and ibotenic acid lesions of nucleus basalis and medial septum produce comparable deficits on delayed nonmatching-to-sample performance in rats. Biopsychol 24:179-186. doi: 10.3758/BF03327034
Related Products: 192-IgG-SAP (Cat. #IT-01)
Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic input.
Baxter MG, Gallagher M (1996) Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic input. Behav Neurosci 110:460-467. doi: 10.1037//0735-7044.110.3.460 PMID: 8888991
Usage: Rats injected with 192-IgG-SAP at 0.506 ug/ul with total volume of 0.3 ul
Related Products: 192-IgG-SAP (Cat. #IT-01)
Intact spatial learning following lesions of basal forebrain cholinergic neurons.
Baxter MG, Sobel TJ, Williams MJ, Gorman LK, Gallagher M (1996) Intact spatial learning following lesions of basal forebrain cholinergic neurons. NeuroReport 7:1417-1420. doi: 10.1097/00001756-199605310-00019 PMID: 8856689
Usage: Rats injected with 192-IgG-SAP (0.506 ug/ul) targeting the basal forebrain
Related Products: 192-IgG-SAP (Cat. #IT-01)
Study of receptor-mediated neurotoxins released by HIV-1-infected, mononuclear phagocytes found in human brain.
Giulian D, Yu J, Li X, Tom D, Li J, Wendt E, Lin S-N, Schwarcz R, Noonan C (1996) Study of receptor-mediated neurotoxins released by HIV-1-infected, mononuclear phagocytes found in human brain. J Neurosci 16:3139-3153. doi: 10.1523/JNEUROSCI.16-10-03139.1996
Related Products: Acetylated LDL-SAP (Cat. #IT-08)
Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft-versus-host disease prophylaxis in haploidentical bone marrow transplantation.
Mavroudis DA, Jiang YZ, Hensel N, Lewalle P, Couriel D, Kreitman RJ, Pastan I, Barrett AJ (1996) Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft-versus-host disease prophylaxis in haploidentical bone marrow transplantation. Bone Marrow Transplant 17:793-799. PMID: 8733700
Related Products: CD25 Mouse Monoclonal (Cat. #AB-18), Anti-CD25-SAP human (Cat. #IT-24)
Effects of intraseptal injection of 192-IgG-saporin in mature and aged Long-Evans rats.
Bannon AW, Curzon P, Gunther KL, Decker MW (1996) Effects of intraseptal injection of 192-IgG-saporin in mature and aged Long-Evans rats. Brain Res 718:25-36. doi: 10.1016/0006-8993(95)01568-x
Related Products: 192-IgG-SAP (Cat. #IT-01)
Lesions of the cholinergic nuclei in the rat basal forebrain: excitotoxins vs. an immunotoxin.
Waite JJ, Thal LJ (1996) Lesions of the cholinergic nuclei in the rat basal forebrain: excitotoxins vs. an immunotoxin. Life Sci 58:1947-1953. doi: 10.1016/0024-3205(96)00184-1
Related Products: 192-IgG-SAP (Cat. #IT-01)
The “combined” 192 IGG saporin lesion approach as an anima model of alzheimer’s disease
Trickle K, Dornan W (1996) The “combined” 192 IGG saporin lesion approach as an anima model of alzheimer’s disease. Illinois Wesleyan Univ Thesis.
Objective: Provide evidence that injections of 192-IgG-SAP both in the medial septal area and the nucleus basalis magnocellularis creates a reliable animal model of Alzheimer’s disease (AD).
Summary: 192-IgG-SAP (IT-01) is a selective cholinergic neurotoxin. Intraventricular injections of 192-IgG-SAP into the lateral ventricles induced a 80-90% reduction of acetylcholine levels in the cortex and hippocampus. Although studies have reported an impairment of spatial learning following treatment by 192-IgG-SAP, the effects observed may be due to loss of cerebellar Purkinje cells following intraventricular injection (i.c.v.). Authors propose that through a combined medial septum and nucleus basalis magnocellularis lesioning technique, a model for AD can be created in a rat that better reflects only damage to strictly cholinergic cells in the impacted regions of the brain.
Usage: Animals received three injections of 192-IgG-SAP into the medial septal area and two (bilateral) injections into the nucleus basalis magnocellularis.
Related Products: 192-IgG-SAP (Cat. #IT-01)