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Retrograde degeneration and colchicine protection of basal forebrain cholinergic neurons following hippocampal injections of an immunotoxin against p75 nerve growth factor receptor.
Ohtake T, Heckers S, Wiley RG, Lappi DA, Mesulam M-M, Geula C (1997) Retrograde degeneration and colchicine protection of basal forebrain cholinergic neurons following hippocampal injections of an immunotoxin against p75 nerve growth factor receptor. Neuroscience 78:123-133. doi: 10.1016/s0306-4522(96)00520-9
Related Products: 192-IgG-SAP (Cat. #IT-01)
Methods of sympathetic degeneration and alteration.
Picklo MJ (1997) Methods of sympathetic degeneration and alteration. J Auton Nerv Syst 62:111-125. doi: 10.1016/s0165-1838(96)00121-x
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Hippocampal N-methyl-D-aspartate and kainate binding in response to entorhinal cortex aspiration or 192 IgG-saporin lesions of the basal forebrain.
Nicolle MM, Shivers A, Gill TM, Gallagher M (1997) Hippocampal N-methyl-D-aspartate and kainate binding in response to entorhinal cortex aspiration or 192 IgG-saporin lesions of the basal forebrain. Neuroscience 77:649-659. doi: 10.1016/s0306-4522(96)00519-2
Related Products: 192-IgG-SAP (Cat. #IT-01)
Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin.
Dornan WA, McCampbell AR, Tinkler GP, Hickman LJ, Bannon AW, Decker MW, Gunther KL (1996) Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin. Behav Brain Res 82:93-101. doi: 10.1016/s0166-4328(97)81112-6
Related Products: 192-IgG-SAP (Cat. #IT-01)
Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings.
Wrenn CC, Picklo MJ, Lappi DA, Robertson DR, Wiley RG (1996) Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings. Brain Res 740:175-186. doi: 10.1016/s0006-8993(96)00855-4
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Lesioning of medullary noradrenergic and adrenergic neurons using the immunotoxin anti-DBH-saporin.
Wrenn CC, Picklo MJ, Lappi DA, Robertson D, Wiley RG (1996) Lesioning of medullary noradrenergic and adrenergic neurons using the immunotoxin anti-DBH-saporin. Neuroscience 1996 Abstracts 749.15. Society for Neuroscience, Washington, DC.
Summary: Anti-DBH-saporin (α-DBH-sap) is an anti-neuronal immunotoxin comprised of an antibody against the noradrenaline synthesizing enzyme dopamine β-hydroxylase (DBH) coupled by a disulfide bond to the ribosome inactivating toxin saporin. This immunotoxin was injected into the left lateral ventricle of rats at doses of 5, 10, and 20 μg. After a two week survival time, the rats were sacrificed and the ability of the immunotoxin to lesion noradrenergic and adrenergic neurons was assessed by immunohistochemical staining for tyrosine hydroxylase (TH), DBH, and phenylethanolamine n-methyl transferase (PNMT). The locus coeruleus was completely lesioned at all three doses. The A5 and A7 cell groups were completely lesioned at the two higher doses. In the medulla, lesioning of the ventrolateral Al/Cl cell group and the dorsomedial A2/C2/C3 cell group was qualitatively observed to be incomplete at all three doses. Cell counts of TH+, DBH+, and PNMT+ neurons revealed that the number of neurons staining for each enzyme was reduced by the immunotoxin dose dependently. The ventrolateral population was lesioned more closely to completeness than the dorsomedial population. These data show that α-DBH-sap can be used to produce lesions of brainstem noradrenergic and adrenergic neurons. Supported by the Department of Veterans Affairs.
Related Products: Anti-DBH-SAP (Cat. #IT-03)
192 IgG-saporin lesion of basal forebrain cholinergic neurons in neonatal rats.
Pappas BA, Davidson CM, Fortin T, Nallathamby S, Park GA, Mohr E, Wiley RG (1996) 192 IgG-saporin lesion of basal forebrain cholinergic neurons in neonatal rats. Brain Res 96:52-61. doi: 10.1016/0165-3806(96)00095-8
Related Products: 192-IgG-SAP (Cat. #IT-01)
Trans-synaptic stimulation of cortical acetylcholine release after partial 192 IgG-saporin-induced loss of cortical cholinergic afferents.
Fadel J, Moore H, Sarter M, Bruno JP (1996) Trans-synaptic stimulation of cortical acetylcholine release after partial 192 IgG-saporin-induced loss of cortical cholinergic afferents. J Neurosci 16:6592-6600. doi: 10.1523/JNEUROSCI.16-20-06592.1996
Related Products: 192-IgG-SAP (Cat. #IT-01)
Intraseptal injection of the cholinergic immunotoxin 192-IgG saporin fails to disrupt latent inhibition in a conditioned taste aversion paradigm.
Dougherty KD, Salat D, Walsh TJ (1996) Intraseptal injection of the cholinergic immunotoxin 192-IgG saporin fails to disrupt latent inhibition in a conditioned taste aversion paradigm. Brain Res 736:260-269. doi: 10.1016/0006-8993(96)00712-3
Related Products: 192-IgG-SAP (Cat. #IT-01)
Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory.
Shen J, Barnes CA, Wenk GL, McNaughton BL (1996) Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory. Behav Neurosci 110:1181-1186. doi: 10.1037//0735-7044.110.5.1181
Related Products: 192-IgG-SAP (Cat. #IT-01)