targeted-toxins

Fadel J, Sarter M, Bruno JP (1999) Age-related attenuation of stimulated cortical acetylcholine release in basal forebrain-lesioned rats. Neuroscience 90:793-802. doi: 10.1016/s0306-4522(98)00515-6

Related Products: 192-IgG-SAP (Cat. #IT-01)

Waite JJ, Wardlow ML, Power AE (1999) Deficit in selective and divided attention associated with cholinergic basal forebrain immunotoxic lesion produced by 192-Saporin; motoric/sensory deficit associated with Purkinje cell immunotoxic lesion produced by OX7-Saporin. Neurobiol Learn Mem 71(3):325-352. doi: 10.1006/nlme.1998.3884

Objective: To distinguish behavioral effects of 192-IgG-SAP due to cerebellar damage versus those due to cholinergic cell loss.

Summary: The cholinergic basal forebrain lesion may mask some of the effects of cerebellar damage up to a threshold after which effects of Purkinje cell loss predominate when 192-IgG-SAP is administered intraventricularly.

Usage: 192-IgG-SAP (1.6, 2.6, and 3.3 ug/rat) and OX7-SAP (2.0 ug/rat) were administered by bilateral icv infusions (5 ul vol/side).

Related Products: 192-IgG-SAP (Cat. #IT-01), OX7-SAP (Cat. #IT-02)

Holschneider DP, Waite JJ, Leuchter AF, Walton NY, Scremin OU (1999) Changes in electrocortical power and coherence in response to the selective cholinergic immunotoxin 192 IgG-Saporin. Exp Brain Res 126:270-280. doi: 10.1007/s002210050736

Related Products: 192-IgG-SAP (Cat. #IT-01)

McGaughy J, Decker MW, Sarter M (1999) Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats. Psychopharmacology (Berl) 144:175-182. doi: 10.1007/s002130050991

Related Products: 192-IgG-SAP (Cat. #IT-01)

Sherren N, Pappas BA, Fortin T (1999) Neural and behavioral effects of intracranial 192 IgG-saporin in neonatal rats: sexually dimorphic effects?. Brain Res Dev Brain Res 114:49-62. doi: 10.1016/s0165-3806(99)00018-8

Related Products: 192-IgG-SAP (Cat. #IT-01)

Pang KCH, Nocera R (1999) Interactions between 192-IgG Saporin and intraseptal cholinergic and GABAergic drugs: role of cholinergic medial septal neurons in spatial working memory. Behav Neurosci 113:265-275. doi: 10.1037//0735-7044.113.2.265

Related Products: 192-IgG-SAP (Cat. #IT-01)

Ridley RM, Barefoot HC, MacLean CJ, Pugh P, Baker HF (1999) Different effects on learning ability after injection of the cholinergic immunotoxin ME20.4 IgG-saporin into the diagonal band of Broca, basal nucleus of Meynert, or both in monkeys. Behav Neurosci 113:303-315. doi: 10.1037//0735-7044.113.2.303

Related Products: ME20.4-SAP (Cat. #IT-15)

Potter PE, Gaughan C, Assouline Y (1999) Lesion of septal-hippocampal neurons with 192 IgG-saporin alters function of M1 muscarinic receptors. Neuropharmacol 38:579-586. doi: 10.1016/s0028-3908(98)00207-x

Related Products: 192-IgG-SAP (Cat. #IT-01)

Baxter M, Chiba A (1999) Cognitive functions of the basal forebrain. Curr Opin Neurobiol 9:178-183. doi: 10.1016/s0959-4388(99)80024-5

Objective: To recent studies of the role of the basal forebrain cholinergic neurons in attention, memory, and cortical information processing, focusing primarily on experiments using the selective cholinergic immunolesion method.

Related Products: 192-IgG-SAP (Cat. #IT-01)

See Also:

• McGaughy J et al. Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behav Neurosci 110:247-265, 1996.
• Waite JJ et al. Deficit in selective and divided attention associated with cholinergic basal forebrain immunotoxic lesion produced by 192-Saporin; motoric/sensory deficit associated with Purkinje cell immunotoxic lesion produced by OX7-Saporin. Neurobiol Learn Mem 71(3):325-352, 1999.

Rossner S, Bakinde N, Zeitschel U, Schliebs R, Bigl V (1999) Cerebrospinal fluid cholinesterases–markers for loss of cholinergic basal forebrain neurons?. Int J Dev Neurosci 16(7-8):669-673. doi: 10.1016/s0736-5748(98)00077-x

Related Products: 192-IgG-SAP (Cat. #IT-01)