targeted-toxins

Martin WJ, Gupta NK, Loo CM, Rohde DS, Basbaum AI (1999) Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing. Pain 80:57-65. doi: 10.1016/s0304-3959(98)00194-8

Summary: The authors used Anti-DBH-SAP to re-examine the contribution of noradrenergic pathways to nociception and to morphine analgesia. They also evaluated morphine analgesia in the formalin test and found that toxin-treated animals exhibited enhanced morphine analgesia. These results establish the utility of using this immunotoxin to selectively destroy subpopulations of noradrenergic cell groups and provide evidence that acute and persistent nociception are differentially regulated by descending noradrenergic pathways.

Usage: Intrathecal treatment with Anti-DBH-SAP attenuates formalin pain (5.0 µg/20 µl).

Related Products: Anti-DBH-SAP (Cat. #IT-03)

Waite JJ, Holschneider DP, Scremin OU (1999) Selective immunotoxin-induced cholinergic deafferentation alters blood flow distribution in the cerebral cortex. Brain Res 818:1-11. doi: 10.1016/s0006-8993(98)01174-3

Related Products: 192-IgG-SAP (Cat. #IT-01)

Llewellyn-Smith IJ, Martin CL, Arnolda LF, Minson JB (1999) Retrogradely transported CTB-saporin kills sympathetic preganglionic neurons. Neuroreport 10(2):307-312. doi: 10.1097/00001756-199902050-00019

Related Products: CTB-SAP (Cat. #IT-14)

Han JS, Holland PC, Gallagher M (1999) Disconnection of the amygdala central nucleus and substantia innominata/nucleus basalis disrupts increments in conditioned stimulus processing in rats. Behav Neurosci 113:143-151. doi: 10.1037//0735-7044.113.1.143

Related Products: 192-IgG-SAP (Cat. #IT-01)

Wiley RG (1999) Molecular murder. Trends in Neurosci 22(2):61. doi: 10.1016/s0166-2236(98)01379-4

Sorger D, Kampfer I, Schliebs R Rossner S, Dannenberg C, Knapp WH (1999) Iodo-QNB cortical binding and brain perfusion: effects of a cholinergic basal forebrain lesion in the rat. Nucl Med Biol 26:9-16. doi: 10.1016/s0969-8051(98)00059-6

Related Products: 192-IgG-SAP (Cat. #IT-01)

Deacon T, Whatley B, LeBlanc C, Lin L, Isacson O (1999) Pig fetal septal neurons implanted into the hippocampus of aged or cholinergic deafferented rats grow axons and form cross-species synapses in appropriate target regions. Cell Transplant 8:111-129. doi: 10.1177/096368979900800104

Related Products: 192-IgG-SAP (Cat. #IT-01)

LeBlanc CJ, Deacon TW, Whatley BR, Dinsmore J, Lin L, Isacson O (1999) Morris water maze analysis of 192-IgG-saporin-lesioned rats and porcine cholinergic transplants to the hippocampus. Cell Transplant 8:131-142. doi: 10.1177/096368979900800105

Related Products: 192-IgG-SAP (Cat. #IT-01)

Wortwein G, Yu J, Toliver-Kinsky T, Perez-Polo JR (1998) Responses of young and aged rat CNS to partial cholinergic immunolwsions and NGF treatment. J Neurosci Res 52:322-333. doi: 10.1002/(SICI)1097-4547(19980501)52:3<322::AID-JNR8>3.0.CO;2-F

Related Products: 192-IgG-SAP (Cat. #IT-01)

McDonald MP, Gleason TC, Robinson JK, Crawley JN (1998) Galanin inhibits performance on rodent memory tasks. Ann NY Acad Sci 863:305-322. doi: 10.1111/j.1749-6632.1998.tb10704.x

Related Products: 192-IgG-SAP (Cat. #IT-01)