targeted-toxins

Sałaciak K, Pytka K (2022) Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders. Neurosci Biobehav Rev 132:1114-1136. doi: 10.1016/j.neubiorev.2021.10.037

Objective: This review focuses on the sigma-1 receptor as a target for treatment of depression and cognitive disorders.

Summary: Sigma-1 receptor ligands, and predominantly agonists, might be the next generation of psychotherapeutic agents.

Usage: 192-IgG-SAP is listed as a neurotoxin that induced a memory impairment in rats based on the Morris water maze.

Related Products: 192-IgG-SAP (Cat. #IT-01)

See Also:

• Antonini V et al. Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J Neurochem 109:744-754, 2009.

Bowers Z, Maiti P, Bourcier A, Morse J, Jenrow K, Rossignol J, Dunbar GL (2021) Tart cherry extract and omega fatty acids reduce behavioral deficits, gliosis, and amyloid-beta deposition in the 5xFAD mouse model of Alzheimer’s disease. Brain Sci 11(11):1423. doi: 10.3390/brainsci11111423 PMID: 34827424

Objective: To assess the efficacy of Total Body Rhythm (TBR) for treating behavioral and neuropathological deficits in the 5xFAD model of AD.

Summary: The combination of tart cherry extract and omega fatty acids in TBR can reduce AD-like deficits in 5xFAD mice.

Usage: Previous work demonstrated that TBR can prevent loss of body weight in a mu p75-SAP mouse model of AD.

Related Products: mu p75-SAP (Cat. #IT-16)

See Also:

• Matchynski JJ et al. Combinatorial treatment of tart cherry extract and essential fatty acids reduces cognitive impairments and inflammation in the mu-p75 saporin-induced mouse model of Alzheimer’s disease. J Med Food 16(4):288-295, 2013.

Miranpuri GS, Bali P, Nguyen J, Kim JJ, Modgil S, Mehra P, Buttar S, Brown G, Yutuc N, Singh H, Wood A, Singh J, Anand A (2021) Role of microglia and astrocytes in spinal cord injury induced neuropathic pain. Ann Neurosci 28(3-4):219-228. doi: 10.1177/09727531211046367

Summary: Given the severity and incapacitating effects of spinal cord injury neuropathic pain (SCINP), it is imperative to study the pathways involved and find new therapeutic targets in coordination with stem cell research, and to develop a new gold-standard in SCINP treatment. Chronic inflammation by microglia, when targeted with Mac-1-SAP, helps in pain reversal.

Related Products: Mac-1-SAP rat (Cat. #IT-33)

Chen ZF (2021) A neuropeptide code for itch. Nat Rev Neurosci 22(12):758-776. doi: 10.1038/s41583-021-00526-9

Related Products: Bombesin-SAP (Cat. #IT-40)

Storozheva ZI, Zakharova EI, Proshin AT (2021) Evaluation of the activity of choline acetyltransferase from different synaptosomal fractions at the distinct stages of spatial learning in the morris water maze. Front Behav Neurosci 15:755373. doi: 10.3389/fnbeh.2021.755373

Objective: To examine the role of hippocampal and cortical ACh in the acquisition, consolidation, storage, retention and adaptive flexibility of new, recent and remote memory traces in spatial learning models.

Summary: The application of functional ablation or stimulation techniques is necessary. The approach used can be regarded as one of the possible ways of delineating temporal stages of spatial learning and could be applied in the studies of other signalling pathways.

Usage: Selective loss of septohippocampal and/or corticopetal cholinergic projections has been shown to cause attention deficit.

Related Products: 192-IgG-SAP (Cat. #IT-01)

See Also:

• McGaughy J et al. Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behav Neurosci 110:247-265, 1996.
• Lehmann O et al. A double dissociation between serial reaction time and radial maze performance in rats subjected to 192 IgG-saporin lesions of the nucleus basalis and/or the septal region. Eur J Neurosci 18(3):651-666, 2003.

Salwa, LK (2021) Engrafted stem cell therapy for Alzheimer’s disease: A promising treatment strategy with clinical outcome. J Control Release 338:837-857. doi: 10.1016/j.jconrel.2021.09.007

Objective: This review provides a detailed update on stem cell therapy (SCT) for Alzheimer’s Disease (AD)

Summary: What future holds for SCT in the treatment of AD is summarized

Usage: Liu et al. injected 1.5 μg of mu p75-SAP into the medial septum.

See: Liu Y et al. Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol 31(5):440-447, 2013.

Read the featured article in Targeting Trends.

Related Products: mu p75-SAP (Cat. #IT-16)

Berthoud HR, Morrison CD, Ackroff K, Sclafani A (2021) Learning of food preferences: mechanisms and implications for obesity & metabolic diseases. Int J Obes (Lond) 45(10):2156-2168. doi: 10.1038/s41366-021-00894-3

Objective: This review focuses on postoral nutrient sensing and signaling as an essential part of the reward system that shapes preferences for the associated flavors of foods.

Summary: There is a critical role for the vagal gut-to-brain axis in motivation and reward. An implication for obesity treatment is that bariatric surgery may alter vagal function.

Usage: Han et al. injected 0.5 µl of CCK-SAP (250 ng/µl) into the R-NG of VGlut2-ires-Cre mice.

See: Han W et al. A Neural Circuit for Gut-Induced Reward. Cell 175:665-678, 2018.

Related Products: CCK-SAP (Cat. #IT-31)

Nobili L, Beniczky S, Eriksson SH, Romigi A, Ryvlin P, Toledo M, Rosenzweig I (2021) Expert Opinion: Managing sleep disturbances in people with epilepsy. Epilepsy Behav 124:108341. doi: 10.1016/j.yebeh.2021.108341

Summary: The authors suggest that the dose and timing of antiepileptic medications and other co-medications should always be optimized in order to improve nocturnal sleep and avoid daytime sedation.

See: Hasegawa H et al. The subcortical belly of sleep: New possibilities in neuromodulation of basal ganglia?. Sleep Med Rev 52:101317, 2020.

Related Products: Orexin-B-SAP (Cat. #IT-20)

Parent MB, Ferreira-Neto HC, Kruemmel AR, Althammer F, Patel AA, Keo S, Whitley KE, Cox DN, Stern JE (2021) Heart failure impairs mood and memory in male rats and down-regulates the expression of numerous genes important for synaptic plasticity in related brain regions. Behav Brain Res 414:113452. doi: 10.1016/j.bbr.2021.113452

Objective: To assess the effects of heart failure (HF) on genetic markers of synaptic plasticity in brain areas critical for memory and mood, and to assess the effects of severely reduced ejection fraction (≤40 %) on cognition regulation.

Summary: Collectively, the present findings provide support for the growing consensus that HF is not only a neurohumoral cardiovascular problem but is also a disorder of mood and memory.

Related Products: 192-IgG-SAP (Cat. #IT-01)

See Also:

• Dobryakova YV et al. Intracerebroventricular administration of 192IgG-saporin alters expression of microglia-associated genes in the dorsal but not ventral hippocampus. Front Mol Neurosci 10:429, 2018.
• Dobryakova YV et al. Cholinergic deficit induced by central administration of 192IgG-Saporin is associated with activation of microglia and cell loss in the dorsal hippocampus of rats. Front Neurosci 13:146, 2019.

Dobryakova YV, Zaichenko MI, Spivak YS, Stepanichev MY, Markevich VA, Bolshakov AP (2021) Overexpression of nerve growth factor in the hippocampus induces behavioral changes in rats with 192IgG-saporin-induced cholinergic deficit. Neurochem J 15:273-281. doi: 10.1134/S1819712421030028

Summary: Degeneration of septal cholinergic neurons caused by the immunotoxin 192-IgG-SAP produces a model of the pathological state that occurs in Alzheimer’s Disease. This study investigated whether overexpression of NGF in the hippocampus, where septal neurons send their projections, may reduce the consequences of this damage. Data suggest that NGF overexpression in the hippocampus of rats may partly compensate some 192 IgG-SAP-induced impairments related to cholinergic deficit.

Usage: 192-IgG-SAP or an equivalent volume of PBS (4 µg/site) was administered bilaterally into the ventricles.

Related Products: 192-IgG-SAP (Cat. #IT-01)