ibro2011

Roach EB, Hussain Shuler MG (2011) Cholinergic denervation disrupts temporal learning in rodent visual cortex. IBRO 2011 Abstracts International Brain Research Organization, Florence, Italy.

Summary: Local cholinergic terminals were removed using the selective neurotoxin 192 IgG-saporin between contingency reversal. This manipulation tested the necessity of cholinergic innervation in two key processes: expressing previously learned reward timing and shifting reward timing to new behaviorally relevant intervals.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Ljubojevic V, Luu P, De Rosa E (2011) The role of cholinergic cortical modulation in visual and olfactory attention using the 5-Choice serial reaction time task. IBRO 2011 Abstracts International Brain Research Organization, Florence, Italy.

Summary: After successful acquisition of both visual and olfactory task, the rats were subjected to either a cholinergic immunotoxic or sham lesion surgery of the NBM. Cholinergic deafferentation of the neocortical mantle was induced by bilaterally infusing the cholinergic immunotoxin, 192 IgG-saporin, into the NBM (0.2 μl of 0.2 μg/μl per site; two sites per hemisphere).

Related Products: 192-IgG-SAP (Cat. #IT-01)

Bajo Lorenzana VM Leach ND, Cordery PM, Nodal FR, King AJ (2011) The cholinergic basal forebrain in the ferret and its inputs to the auditory cortex. IBRO 2011 Abstracts International Brain Research Organization, Florence, Italy.

Summary: Projections from the NB to the auditory cortex were investigated by injecting tracers into the NB itself (n=5), or by applying tracer deposits to the surface of the auditory cortex (n=4). Tracers included Rhodamine, Fluorescein, Cascade Blue, as well as the cholinergic immunotoxin ME20.4-SAP. Both ME20.4-SAP injections in the auditory cortex and epipial tracer deposits revealed that NB provides the main cholinergic input to the cortex, and that this projection is predominantly ipsilateral.

Related Products: ME20.4-SAP (Cat. #IT-15)

Gulino R, Gulisano M (2011) A central role for BDNF and Sonic Hedgehog in controlling synaptic plasticity in motoneuron-depleted spinal cord. IBRO 2011 Abstracts International Brain Research Organization, Florence, Italy.

Summary: Here, we measured the expression levels of several proteins involved in synaptic plasticity and motoneuronal function (ChAT, Synapsin-I, Shh, Notch-1, AMPA receptor subunits, NMDA receptor and BDNF) in a mouse SC lesion model obtained by intramuscular injection of Cholera toxin-B-saporin, which selectively kills motoneurons

Related Products: CTB-SAP (Cat. #IT-14)