antibodies

Li J, Xiang X, Xu H, Shi Y (2019) Cilostazol promotes angiogenesis and increases cell proliferation after myocardial ischemia–reperfusion injury through a camp-dependent mechanism. Cardiovasc Eng Technol 10(4):638-647. doi: 10.1007/s13239-019-00435-0 PMID: 31625080

Usage: western

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Avrampou K, Pryce KD, Ramakrishnan A, Sakloth F, Gaspari S, Serafini RA, Mitsi V, Polizu C, Swartz C, Ligas B, Richards A, Shen L, Carr FB, Zachariou V (2019) RGS4 maintains chronic pain symptoms in rodent models. J Neurosci 39(42):8291-8304. doi: 10.1523/JNEUROSCI.3154-18.2019 PMID: 31308097

Usage: western

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Martins JR, Reichhart N, Kociok N, Stindl J, Foeckler R, Lachmann P, Todorov V, Castrop H, Strauß O (2019) Systemic ß adrenergic stimulation/ sympathetic nerve system stimulation influences intraocular RAS through cAMP in the RPE. Exp Eye Res 189:107828. doi: 10.1016/j.exer.2019.107828 PMID: 31589840

Objective: To investigate whether systemic β-adrenergic stimulation of the retinal pigment epithelium (RPE) also modulates renin expression in the RPE.

Summary: In vitro analysis of renin gene expression using polarized porcine RPE showed that the activity of the renin promoter can be increased by cAMP stimulation (IBMX/forskolin) but was not influenced by angiotensin-2.

Usage: Immunohistochemistry; eye sections were labeled overnight at 4°C with Anti-AT-1R.

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Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R (2019) Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses. FASEB J 33(12):13734-13746. doi: 10.1096/fj.201901543R PMID: 31585509

Usage: immunohistochemistry (1:150)

Related Products: Metabotropic Glutamate Receptor 2 (mGluR2) Mouse Monoclonal (Cat. #AB-N32)

Zhuo X, Wu Y, Yang Y, Gao L, Qiao X, Chen T (2019) LncRNA AK094457 promotes AngII-mediated hypertension and endothelial dysfunction through suppressing of activation of PPARγ. Life Sci 233:116745. doi: 10.1016/j.lfs.2019.116745 PMID: 31404524

Objective: To find the functional lncRNAs associated with hypertension, high throughput lncRNA microarray were used to analyze expression profile of the lncRNAs in the aortic vascular endothelial cells of spontaneously hypertensive rats.

Summary: lncRNA AK094457 is identified as a key regulator in blood pressure and endothelial function, which can increase AngII-induced hypertension and endothelial dysfunction via suppression of PPARγ.

Usage: Western Blot (1:500), immunohistochemistry

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Bülbül M, Sinen O, Bayramoğlu O, Akkoyunlu G (2019) Enteric apelin enhances the stress-induced stimulation of colonic motor functions. Stress 23(2):201-212. doi: 10.1080/10253890.2019.1658739 PMID: 31441348

Usage: histology (1:100)

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Ladd MR, Costello CM, Gosztyla C, Werts AD, Johnson B, Fulton WB, Martin LY, Redfield EJ, Crawford B, Panaparambil R, Sodhi CP, March JC, Hackam DJ (2019) Development of intestinal scaffolds that mimic native mammalian intestinal tissue. Tissue Eng Part A 25(17-18):1225-1241. doi: 10.1089/ten.TEA.2018.0239 PMID: 30652526

Objective: To develop a scaffold for the generation of an artificial intestine that specifically mimics the architecture and biomechanical properties of the native small intestine, and to evaluate the scaffold in vitro and in vivo.

Summary: Novel scaffolds were developed using PGS with promise for use in artificial intestine for individuals with short bowel syndrome.

Usage: Histology, immunohistochemistry, microscopy (1:500)

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Saw S, Aiken A, Fang H, McKee TD, Bregant S, Sanchez O, Chen Y, Weiss A, Dickson BC, Czarny B, Sinha A, Fosang A, Dive V, Waterhouse PD, Kislinger T, Khokha R (2019) Metalloprotease inhibitor timp proteins control FGF-2 bioavailability and regulate skeletal growth. J Cell Biol 218(9):3134-3152. doi: 10.1083/jcb.201906059 PMID: 31371388

Usage: immunostaining (1:100)

Related Products: Fibroblast Growth Factor Rabbit Polyclonal, mammalian (Cat. #AB-07)

Małecki JM, Willemen HLDM, Pinto R, Ho AYY, Moen A, Eijkelkamp N, Falnes PØ (2019) Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration. J Biol Chem 294(31):11654-11664. doi: 10.1074/jbc.RA119.009045 PMID: 31213526

Usage: Western blot

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Suwannasual U, Lucero J, Davis G, McDonald JD, Lund AK (2019) Mixed vehicle emissions induces angiotensin ii and cerebral microvascular angiotensin receptor expression in C57Bl/6 mice and promotes alterations in integrity in a blood-brain barrier coculture model. Toxicol Sci 170(2):525-535. doi: 10.1093/toxsci/kfz121 PMID: 31132127

Objective: To investigate the hypothesis that inhalation exposure to a mixture of gasoline and diesel vehicle engine emissions (MVE) results in altered central nervous system microvascular integrity mediated by Ang II-AT1 signaling.

Summary: Inhalation exposure to traffic-generated pollutants results in altered BBB integrity, mediated through Ang II-AT1 signaling and inflammation, which is exacerbated by a high-fat diet.

Usage: Antibody was used in immunofluorescent staining of cerebral tissue. Brain sections (10 mm) were prepared for AT1 receptor (1:1000).

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)