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Angiotensin II receptor
Angiotensin II’s role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: amygdalar angiotensin receptors and panic
Johnson PL, Sajdyk TJ, Fitz SD, Hale MW, Lowry CA, Hay-Schmidt A, Shekhar A (2013) Angiotensin II’s role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: amygdalar angiotensin receptors and panic. Prog Neuropsychopharmacol Biol Psychiatry 44:248-256. doi: 10.1016/j.pnpbp.2013.02.014 PMID: 23523745
Objective: To test the hypothesis that the subfornical organ (SFO) projects to the basolateral amygdala (BLA) and releases angiotensin-II (A-11) to mobilize panic responses.
Summary: The presence of AT-1R was confirmed in the BLA which, combined with previous data, suggests that A-II’s panicogenic effects in the BLA are AT-1R dependent.
Usage: Immunohistochemistry (1:250 to 1:500).
Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)
A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia
Smith MT, Woodruff TM, Wyse BD, Muralidharan A, Walther T (2013) A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. Pain Med 14(10):1557-1568. doi: 10.1111/pme.12157 PMID: 23742186
Objective: To elucidate the mechanism through which EMA300, a small molecule antagonist of the angiotensin II type 2 receptor (AT2R) with >1,000-fold selectivity over the angiotensin II type 1 receptor, produces analgesia in a rodent model of neuropathic pain.
Summary: Augmented angiotensin II/AT2R signaling in the DRGs of CCI rats is attenuated by EMA300 to block p38 MAPK and p44/p42 MAPK activation, a mechanism with clinical validity for alleviating neuropathic pain.
Usage: Immunostaining (1:250), rat DRG sections
Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)
Immunohistochemical localization of AT1a, AT1b, and AT2 Angiotensin II receptor subtypes in the rat adrenal, pituitary, and brain with a perspective commentary.
Premer C, Lamondin C, Mitzey A, Speth R, Brownfield M (2013) Immunohistochemical localization of AT1a, AT1b, and AT2 Angiotensin II receptor subtypes in the rat adrenal, pituitary, and brain with a perspective commentary. Int J Hypertens 2013:175428. doi: 10.1155/2013/175428 PMID: 23573410
Objective: To immunohistochemically differentiate the angiotensin receptor subtypes: AT-1ARa, AT-1ARb, and AT-2R.
Summary: Antibodies that can differentiate the three different angiotensin II receptor subtypes in the rat were used to immunohistochemically label angiotensin II receptor subtype-like immunoreactivity in the rat adrenal, pituitary, and brain. The pattern of staining corroborates mRNA, radioligand binding, and functional studies of adrenal and anterior pituitary angiotensin receptors.
Usage: Western blot (1:500), immunofluorescence (1:500), immunocytochemistry (AB-N25AP and AB-N26AP at 1:500, AB-N28AP at 1:2000).
Related Products: Angiotensin II receptor (AT-1AR) Rabbit Polyclonal, affinity-purified (Cat. #AB-N25AP), Angiotensin II receptor (AT-1BR) Rabbit Polyclonal, affinity-purified (Cat. #AB-N26AP), Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)
Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus.
Shekhar A, Johnson PL, Sajdyk TJ, Fitz SD, Keim SR, Kelley PE, Gehlert DR, DiMicco JA (2006) Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus. J Neurosci 26(36):9205-9215. doi: 10.1523/JNEUROSCI.2491-06.2006 PMID: 16957077
Objective: To determine the exact mechanism for lactate to elicit a panic attack.
Summary: Results implicate A-II pathways and the A-II receptors (AT-1Ra, AT-1Rb) in the hypothalamus as putative substrates for sodium lactate-induced panic-like responses in vulnerable subjects.
Usage: Immunohistochemistry (1:500), Western blot (1:500)
Related Products: Angiotensin II receptor (AT-1AR) Rabbit Polyclonal, affinity-purified (Cat. #AB-N25AP), Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)
NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius.
Wang G, Anrather J, Huang J, Speth RC, Pickel VM, Iadecola C (2004) NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius. J Neurosci 24(24):5516-5524. doi: 10.1523/JNEUROSCI.1176-04.2004 PMID: 15201324
Objective: To investigated whether NADPH oxidase is involved in angiotensin II signaling in central autonomic neurons.
Summary: Angiotensin II (AngII), acting through angiotensin type 1 (AT1 ) receptors, exerts powerful effects on central autonomic networks regulating cardiovascular homeostasis and fluid balanceColocalization of AT-1r’s and a NADPH oxidase subunit provides evidence that NADPH oxidase is involved in the effects of angiotensin II on autonomic neurons.
Usage: Immunolabeling (1:200)
Related Products: Angiotensin II receptor (AT-1AR) Rabbit Polyclonal, affinity-purified (Cat. #AB-N25AP), Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP), Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)
Angiotensin II subtype 1A (AT1A) receptors in the rat sensory vagal complex: Subcellular localization and association with endogenous angiotensin.
Huang J, Hara Y, Anrather J, Speth RC, Iadecola C, Pickel VM (2003) Angiotensin II subtype 1A (AT1A) receptors in the rat sensory vagal complex: Subcellular localization and association with endogenous angiotensin. Neuroscience 122(1):21-36. doi: 10.1016/s0306-4522(03)00606-7 PMID: 14596846
Objective: To determine interactive sites in the sensory vagal complex of rat brain using dual immunolabeling of antisera recognizing the AT1-AR and Ang II.
Summary: In the rat sensory vagal complex, AT-1A receptors are strategically positioned for involvement in modulation of the postsynaptic excitability and intracrine hormone-like effects of Ang II. In addition, these receptors have distributions consistent with diverse roles in regulation of transmitter release, regional blood flow and/or vascular permeability.
Usage: Immunolabeling (1:200)
Related Products: Angiotensin II receptor (AT-1AR) Rabbit Polyclonal, affinity-purified (Cat. #AB-N25AP), Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP), Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)
Immunohistochemical localization of AT-1A and AT-1B angiotensin II receptor subtypes in the rat adrenal
Speth RC, Grove KL, Brownfield MS (2001) Immunohistochemical localization of AT-1A and AT-1B angiotensin II receptor subtypes in the rat adrenal. Endocrine Society ENDO 2001 – 83rd Annual Meeting of the Endocrine Society, Denver, Colorado. PMID: 909090
Related Products: Angiotensin II receptor (AT-1AR) Rabbit Polyclonal, affinity-purified (Cat. #AB-N25AP)