Shekhar A, Johnson PL, Sajdyk TJ, Fitz SD, Keim SR, Kelley PE, Gehlert DR, DiMicco JA (2006) Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus. J Neurosci 26(36):9205-9215. doi: 10.1523/JNEUROSCI.2491-06.2006 PMID: 16957077
Objective: To determine the exact mechanism for lactate to elicit a panic attack.
Summary: Results implicate A-II pathways and the A-II receptors (AT-1Ra, AT-1Rb) in the hypothalamus as putative substrates for sodium lactate-induced panic-like responses in vulnerable subjects.
Usage: Immunohistochemistry (1:500), Western blot (1:500)
Related Products: Angiotensin II receptor (AT-1AR) Rabbit Polyclonal, affinity-purified (Cat. #AB-N25AP), Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)