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Enteric neurodegeneration is mediated through independent neuritic and somal mechanisms in rotenone and MPP+ toxicity.
Virga DM, Capps J, Vohra BPS (2018) Enteric neurodegeneration is mediated through independent neuritic and somal mechanisms in rotenone and MPP+ toxicity. Neurochem Res 43(12):2288-2303. doi: 10.1007/s11064-018-2649-x PMID: 30259276
Objective: To investigate the mechanism by which enteric nervous system degeneration occurs in Parkinson’s Disease.
Summary: Therapies targeting both axonal and somal protection can be important in finding interventions for enteric symptoms in PD.
Usage: P75NTR antibody utilized (1:1000) to immunoselect enteric neural crest from the rest of the cells in the gut including stomach, small and large bowl and colon) from E12.5 Sprague CD1 mice.
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Cross-talk between distinct receptors shapes itch behavior in the spinal cord.
Meng QT, Liu XY, Liu XT, Barry DM, Jin H, Yang Q, Sun Y, Wan L, Jin JH, Munanairi A, Kim R, Yin J, Tao A, Chen ZF (2018) Cross-talk between distinct receptors shapes itch behavior in the spinal cord. Neuron doi: 10.2139/ssrn.3249822
Summary: Consistently, Nppb-SAP ablated spinal Npr1 and Npr3 neurons and impaired histamine-, but not CQ-evoked, itch. Thus, the findings identify the role of BNP-NPRC signaling in modulation of histamine-evoked itch via NPRC-NMBR cross-talk independent of GRP-GRPR signaling. Our studies reveal distinct modes of action for bombesin-related peptides and NP in itch transmission.
Related Products: Nppb-SAP (Cat. #IT-69)
Neuropharmacology of attention
Burk JA, Blumenthal SA, Maness EB (2018) Neuropharmacology of attention. Eur J Pharmacol 835:162-168. doi: 10.1016/j.ejphar.2018.08.008
Objective: This review focuses on the knowledge gained about neurotransmitter systems with respect to attentional processing, with emphasis on the functions mediated within the medial prefrontal cortex.
Summary: Future research needs to facilitate a better comprehension of the neural circuitry engaged by different subcategories of attention. Such information will be useful in allowing for more targeted treatments for conditions characterized by attentional deficits.
Usage: Several citations using 192-IgG-SAP;. The specific role of ACh in attentional function can be examined with lesions to cholinergic inputs to the mPFC, using the immunotoxin 192 immunoglobulin G (IgG) saporin. Increases in mPFC ACh efflux related to attention are no longer present following cholinergic lesions. These cholinergic lesions lead to severe deficits in performance on both sustained attention and 5CSRTT-related tasks.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer
Su Y, Liu Y, Behrens CR, Bidlingmaier S, Lee NK, Aggarwal R, Sherbenou DW, Burlingame AL, Hann BC, Simko JP, Premasekharan G, Paris PL, Shuman MA, Seo Y, Small EJ, Liu B (2018) Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI Insight 3(17):e121497. doi: 10.1172/jci.insight.121497 PMID: 30185663
Objective: To investigate the suitability of a CD46 antibody as a metastatic castration-resistant prostate cancer (mCRPC) anti-tumor agent.
Summary: CD46 is an excellent candidate for antibody-based therapy development, which has potential to be applicable to both adenocarcinoma and neuroendocrine types of mCRPC that are resistant to current treatment.
Usage: Biotinylated UA20 IgG and Streptavidin-ZAP were mixed at a molar ratio of 1:1. The conjugate was used in cytotoxicity assays and shown to specifically kill the mCRPC cells.
Related Products: Streptavidin-ZAP (Cat. #IT-27)
Molecular diversity of intrinsically photosensitive ganglion cells
Berg D, Kartheiser K, Leyrer M, Saali A, Berson D (2018) Molecular diversity of intrinsically photosensitive ganglion cells. bioRxiv 381004. doi: 10.1101/381004
Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)
Cell subpopulations overexpressing p75NTR have tumor-initiating properties in the c6 glioma cell line
Yang WH, Cheng CY, Chen MF, Wang TC (2018) Cell subpopulations overexpressing p75NTR have tumor-initiating properties in the c6 glioma cell line. 38(9):5183-5192. doi: 10.21873/anticanres.12841 PMID: 30194166
Objective: This study is focused on the possible role of p75NTR in glioma tumor initiation.
Summary: Cells with p75NTR overexpression demonstrated certain unique characteristics of tumor-initiating cells, such as neurosphere formation, high colony proliferation, and resistance to radio- and chemotherapy. With regard to the heterogeneous composition of glioma cells, p75NTR can be used as an alternative marker to identify a glioma subpopulation with tumor-initiating properties.
Usage: flow cytometry
Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)
Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation.
Lénárd L, László K, Kertes E, Ollmann T, Péczely L, Kovács A, Kállai V, Zagorácz O, Gálosi R, Karádi Z (2018) Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation. Neurosci Biobehav Rev 85:1-20. doi: 10.1016/j.neubiorev.2017.09.003
Summary: A specific neurotoxin, SSP-SAP can cause selective ablation of NK1 receptor expressing cells. This lesion in the BLA of rats resulted in anxiogenic effect, while in the CeA had no effect in EPM test.
Related Products: SSP-SAP (Cat. #IT-11)
The angiotensin II type 2 receptors protect renal tubule mitochondria in early stages of diabetes mellitus
Micakovic T, Papagiannarou S, Clark E, Kuzay Y, Abramovic K, Peters J, Sticht C, Volk N, Fleming T, Nawroth P, Hammes HP, Alenina N, Grone HJ, Hoffmann SC (2018) The angiotensin II type 2 receptors protect renal tubule mitochondria in early stages of diabetes mellitus. Kidney Int 94:937-950. doi: 10.1016/j.kint.2018.06.006 PMID: 30190172
Objective: To investigate the role of the angiotensin II type 2 receptor (AT-2R) at the early stages of diabetic nephropathy.
Summary: Targeted AT-2R overexpression in renal cells may open new avenues to develop novel types of drugs preventing diabetic nephropathy.
Usage: Histology, immunohistochemistry; 1:100
Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)
Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons
Donnelly CR, Gabreski NA, Suh EB, Chowdhury M, Pierchala BA (2018) Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons. J Cell Biol 217:327. doi: 10.1083/jcb.201703120 PMID: 30018091
Summary: The authors investigated the interactions of pro-survival and pro-apoptotic receptors in Programmed Cell Death (PCD) using the sympathetic nervous system as a model. They demonstrate that Ret, a receptor tyrosine kinase required for the survival of many neuronal populations, is restricted to a subset of degenerating neurons that rapidly undergo apoptosis.
Usage: Proximity ligation assays (1:500); Western blotting (1:1,000)
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Molecular, cellular and circuit basis of cholinergic modulation of pain
Naser PV, Kuner R (2018) Molecular, cellular and circuit basis of cholinergic modulation of pain. Neuroscience 387:135-148. doi: 10.1016/j.neuroscience.2017.08.049
Related Products: 192-IgG-SAP (Cat. #IT-01)