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Attenuation of angiotensin II–induced hypertension in BubR1 low‐expression mice via repression of angiotensin II receptor 1 overexpression.
Aoyagi Y, Furuyama T, Inoue K, Matsuda D, Matsubara Y, Okahara A, Ago T, Nakashima Y, Mori M, Matsumoto T (2019) Attenuation of angiotensin II–induced hypertension in BubR1 low‐expression mice via repression of angiotensin II receptor 1 overexpression. J Am Heart Assoc 8(23):e011911. doi: 10.1161/JAHA.118.011911 PMID: 31787052
Usage: western blot
Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)
Evidence that the LH surge in ewes involves both neurokinin B–dependent and –independent actions of kisspeptin.
Goodman RL, He W, Lopez JA, Bedenbaugh MN, McCosh RB, Bowdridge EC, Coolen LM, Lehman MN, Hileman SM (2019) Evidence that the LH surge in ewes involves both neurokinin B–dependent and –independent actions of kisspeptin. Endocrinology 160(12):2990-3000. doi: 10.1210/en.2019-00597
Objective: To determine if NKB is involved in the RCh of the ewe in the LH surge.
Summary: NKB signaling in the RCh increases kisspeptin levels critical for the full amplitude of the LH surge in the ewe, but kisspeptin release occurs independently of retrochiamatic area (RCh) input at the onset of the surge to initiate GnRH secretion.
Usage: Bilaterial injections in the RCh of either NK3-SAP or Blank-SAP.
Related Products: NKB-SAP (Cat. #IT-63), Blank-SAP (Cat. #IT-21)
BDNF downregulates β-adrenergic receptor-mediated hypotensive mechanisms in the paraventricular nucleus of the hypothalamus.
Thorsdottir D, Cruickshank NC, Einwag Z, Hennig GW, Erdos B (2019) BDNF downregulates β-adrenergic receptor-mediated hypotensive mechanisms in the paraventricular nucleus of the hypothalamus. Am J Physiol Heart Circ Physiol 317(6):H1258-H1271. doi: 10.1152/ajpheart.00478.2019
Objective: To determine whether BDNF increases blood pressure in part by diminishing inhibitory hypotensive input from nucleus of the solitary tract (NTS) catecholaminergic neurons projecting to the PVN.
Summary: BDNF, a key hypothalamic regulator of blood pressure, disrupts catecholaminergic signaling between the NTS and the PVN by reducing the responsiveness of PVN neurons to inhibitory hypotensive β-adrenergic input from the NTS.
Usage: Bilateral NTS injections of sterile PBS (for control) or Anti-DBH-SAP (22 ng).
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Rostral ventrolateral medullary catecholaminergic neurones mediate irregular breathing pattern in volume overload heart failure rats.
Toledo C, Andrade DC, Díaz HS, Pereyra KV, Schwarz KG, Díaz-Jara E, Oliveira LM, Takakura AC, Moreira TS, Schultz HD, Marcus NJ, Del Rio R (2019) Rostral ventrolateral medullary catecholaminergic neurones mediate irregular breathing pattern in volume overload heart failure rats. J Physiol 597(24):5799-5820. doi: 10.1113/JP278845
Objective: To investigate the potential contribution of RVLM‐C1 neurons to irregular breathing.
Summary: Findings suggest that RVLM‐C1 neurons play a pivotal role in breathing irregularities in volume overload HF, and mediate the sympathetic responses induced by acute central chemoreflex activation.
Usage: Anti-DBH-SAP was used to selectively lesion RVLM‐C1 neurons. Reduction (∼65%) of RVLM‐C1 neurons resulted in attenuation of irregular breathing, decreased apnea‐hypopnea incidence and improved cardiac autonomic control.
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Qishen Granule improved cardiac remodeling via balancing M1 and M2 macrophages
Lu W, Wang Q, Sun X, He H, Wang Q, Wu Y, Liu Y, Wang Y, Li C (2019) Qishen Granule improved cardiac remodeling via balancing M1 and M2 macrophages. Front Pharmacol 10:1399. doi: 10.3389/fphar.2019.01399 PMID: 31824322
Objective: To explore the effect of Qishen Granule (QSG) on the release of splenic monocytes, the recruitment of monocytes into heart tissues and the differentiation of macrophages under ischemic conditions.
Summary: Compounds of Chinese medicine have synergistic effects on cardiac and splenic organs through regulating differentiation of monocytes/macrophages in inhibiting myocardial remodeling.
Usage: Western blot
Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)
Episodic stimulation of central chemoreflex elicits long-term breathing disorders and autonomic imbalance in heart failure rats.
Díaz HS, Andrade DC, Toledo C, Lucero C, Arce-Álvarez A, Del Rio R (2019) Episodic stimulation of central chemoreflex elicits long-term breathing disorders and autonomic imbalance in heart failure rats. Eur Respir J 54(suppl 63):OA4936. doi: 10.1183/13993003.congress-2019.OA4936
Objective: To determine the role of CC in the development of cardiorespiratory dysfunction in a HF model.
Summary: Rats were exposed to pisodic hypercapnic stimulation (EHS) The effects of EHS in rats with heart failure were attenuated by SSP-SAP treatment.
Usage: Selective destruction of chemoreceptor neurons within the retrotapezoid nucleus (RTN) was performed via SSP-SAP injections (0.6 ng/30 nL).
Related Products: SSP-SAP (Cat. #IT-11)
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer
Zurlo G, Liu X, Takada M, Fan C, Simon JM, Ptacek TS, Rodriguez J, von Kriegsheim A, Liu J, Locasale JW, Robinson A, Zhang J, Holler JM, Kim B, Zikánová M, Bierau J, Xie L, Chen X, Li M, Perou CM, Zhang Q (2019) Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer. Nat Commun 10(1):5177. doi: 10.1038/s41467-019-13168-4 PMID: 31729379
Objective: To investigate the role of ADSL hydroxylation in controlling cMYC and triple negative breast cancer (TNBC) tumorigenesis.
Summary: ADSL regulates cMYC protein level through adenosine levels and leads to downstream metabolic changes and breast cancer cell proliferation. ADSL is essential for TNBC cell growth and invasiveness and contributes to TNBC breast tumorigenesis and metastasis in vivo.
Usage: Western blot
Related Products: Trans-4-Hydroxy-L-Proline Rabbit Polyclonal, Conjugated (Cat. #AB-T044)
OP11: Role of spinal cholecystokinin receptor 2 in alloknesis models.
Tominaga M, Kusube F, Honda K, Komiya E, Takahashi N, Naito H, Suga Y, Takamori K (2019) OP11: Role of spinal cholecystokinin receptor 2 in alloknesis models. Itch 4:1-62. doi: 10.1097/itx.0000000000000030
Objective: To determine the detailed molecular and cellular mechanisms that induce alloknesis via the spinal CCK2 receptor.
Summary: Ablation of spinal CCK receptor-expressing cells by i.t. injection of CCK-SAP attenuated CCK8S-induced alloknesis in comparison with Blank-SAP control mice.
Usage: Intrathecal injection
Related Products: CCK-SAP (Cat. #IT-31), Blank-SAP (Cat. #IT-21)
Systems pathology of neuropathic pain and fibromyalgia.
Ueda H (2019) Systems pathology of neuropathic pain and fibromyalgia. Biol Pharm Bull 42(11):1773-1782. doi: 10.1248/bpb.b19-00535
Related Products: Mac-1-SAP mouse/human (Cat. #IT-06)
Renal denervation for treating congenital long QT syndrome: Shortening the QT interval or modulating sympathetic tone?
Kiuchi MG, Chen S, Carnagarin R, Matthews VB, Schlaich MP (2019) Renal denervation for treating congenital long QT syndrome: Shortening the QT interval or modulating sympathetic tone?. Europace 21(11):1755-1756. doi: 10.1093/europace/euz251
Summary: Targeted ablation of cardiac sympathetic neurons (TACSN) through CTB-SAP injection in the left stellate ganglion (LSG), inhibited its activation, improved sympathetic remodelling, and restored cardiac autonomic balance.
Related Products: CTB-SAP (Cat. #IT-14)