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CR3 (alphaM beta2; CD11b/CD18) restores IgG-dependent phagocytosis in transfectants expressing a phagocytosis-defective Fc gammaRIIA (CD32) tail-minus mutant.
Worth RG, Mayo-Bond L, van de Winkel JG, Todd RF 3rd, Petty HR (1996) CR3 (alphaM beta2; CD11b/CD18) restores IgG-dependent phagocytosis in transfectants expressing a phagocytosis-defective Fc gammaRIIA (CD32) tail-minus mutant. J Immunol 157(12):5660-5665. PMID: 8955219
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Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin.
Dornan WA, McCampbell AR, Tinkler GP, Hickman LJ, Bannon AW, Decker MW, Gunther KL (1996) Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin. Behav Brain Res 82:93-101. doi: 10.1016/s0166-4328(97)81112-6
Related Products: 192-IgG-SAP (Cat. #IT-01)
Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations of Golgi cells in the rat cerebellum.
Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N (1996) Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations of Golgi cells in the rat cerebellum. Neuroscience 75(3):815-826. doi: 10.1016/0306-4522(96)00316-8 PMID: 8951875
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Impact of social confrontation on rat CD4 T cells bearing different CD45R isoforms.
Stefanski V, Solomon GF, Kling AS, Thomas J, Plaeger S (1996) Impact of social confrontation on rat CD4 T cells bearing different CD45R isoforms. Brain Behav Immun 10(4):364-379. doi: 10.1006/brbi.1996.0032 PMID: 9045751
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Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings.
Wrenn CC, Picklo MJ, Lappi DA, Robertson DR, Wiley RG (1996) Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings. Brain Res 740:175-186. doi: 10.1016/s0006-8993(96)00855-4
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Lesioning of medullary noradrenergic and adrenergic neurons using the immunotoxin anti-DBH-saporin.
Wrenn CC, Picklo MJ, Lappi DA, Robertson D, Wiley RG (1996) Lesioning of medullary noradrenergic and adrenergic neurons using the immunotoxin anti-DBH-saporin. Neuroscience 1996 Abstracts 749.15. Society for Neuroscience, Washington, DC.
Summary: Anti-DBH-saporin (α-DBH-sap) is an anti-neuronal immunotoxin comprised of an antibody against the noradrenaline synthesizing enzyme dopamine β-hydroxylase (DBH) coupled by a disulfide bond to the ribosome inactivating toxin saporin. This immunotoxin was injected into the left lateral ventricle of rats at doses of 5, 10, and 20 μg. After a two week survival time, the rats were sacrificed and the ability of the immunotoxin to lesion noradrenergic and adrenergic neurons was assessed by immunohistochemical staining for tyrosine hydroxylase (TH), DBH, and phenylethanolamine n-methyl transferase (PNMT). The locus coeruleus was completely lesioned at all three doses. The A5 and A7 cell groups were completely lesioned at the two higher doses. In the medulla, lesioning of the ventrolateral Al/Cl cell group and the dorsomedial A2/C2/C3 cell group was qualitatively observed to be incomplete at all three doses. Cell counts of TH+, DBH+, and PNMT+ neurons revealed that the number of neurons staining for each enzyme was reduced by the immunotoxin dose dependently. The ventrolateral population was lesioned more closely to completeness than the dorsomedial population. These data show that α-DBH-sap can be used to produce lesions of brainstem noradrenergic and adrenergic neurons. Supported by the Department of Veterans Affairs.
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Contributions of donor and host blood vessels in CNS allografts.
Baker-Cairns BJ, Sloan DJ, Broadwell RD, Puklavec M, Charlton HM (1996) Contributions of donor and host blood vessels in CNS allografts. Exp Neurol 142(1):36-46. doi: 10.1006/exnr.1996.0177 PMID: 8912897
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Assembly of the herpes simplex virus capsid: characterization of intermediates observed during cell-free capsid formation
Newcomb WW, Homa FL, Thomsen DR, Booy FP, Trus BL, Steven AC, Spencer JV, Brown JC (1996) Assembly of the herpes simplex virus capsid: characterization of intermediates observed during cell-free capsid formation. J Mol Biol 263(3):432-446. doi: 10.1006/jmbi.1996.0587 PMID: 8918599
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192 IgG-saporin lesion of basal forebrain cholinergic neurons in neonatal rats.
Pappas BA, Davidson CM, Fortin T, Nallathamby S, Park GA, Mohr E, Wiley RG (1996) 192 IgG-saporin lesion of basal forebrain cholinergic neurons in neonatal rats. Brain Res 96:52-61. doi: 10.1016/0165-3806(96)00095-8
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Trans-synaptic stimulation of cortical acetylcholine release after partial 192 IgG-saporin-induced loss of cortical cholinergic afferents.
Fadel J, Moore H, Sarter M, Bruno JP (1996) Trans-synaptic stimulation of cortical acetylcholine release after partial 192 IgG-saporin-induced loss of cortical cholinergic afferents. J Neurosci 16:6592-6600. doi: 10.1523/JNEUROSCI.16-20-06592.1996
Related Products: 192-IgG-SAP (Cat. #IT-01)