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Different effects on learning ability after injection of the cholinergic immunotoxin ME20.4 IgG-saporin into the diagonal band of Broca, basal nucleus of Meynert, or both in monkeys.
Ridley RM, Barefoot HC, MacLean CJ, Pugh P, Baker HF (1999) Different effects on learning ability after injection of the cholinergic immunotoxin ME20.4 IgG-saporin into the diagonal band of Broca, basal nucleus of Meynert, or both in monkeys. Behav Neurosci 113:303-315. doi: 10.1037//0735-7044.113.2.303
Related Products: ME20.4-SAP (Cat. #IT-15)
Interactions between 192-IgG Saporin and intraseptal cholinergic and GABAergic drugs: role of cholinergic medial septal neurons in spatial working memory.
Pang KCH, Nocera R (1999) Interactions between 192-IgG Saporin and intraseptal cholinergic and GABAergic drugs: role of cholinergic medial septal neurons in spatial working memory. Behav Neurosci 113:265-275. doi: 10.1037//0735-7044.113.2.265
Related Products: 192-IgG-SAP (Cat. #IT-01)
Detection of nitrosylated epitopes in Trypanosoma brucei gambiense by polyclonal and monoclonal anti-conjugated-NO-cysteine antibodies.
Mnaimneh S, Geffard M, Veyret B, Vincendeau P (1999) Detection of nitrosylated epitopes in Trypanosoma brucei gambiense by polyclonal and monoclonal anti-conjugated-NO-cysteine antibodies. C R Acad Sci III 322(4):311-322. doi: 10.1016/s0764-4469(99)80067-5 PMID: 10216803
Related Products: NO-L-Cysteine Mouse Monoclonal, Conjugated (Cat. #AB-T125)
Interleukin-2 (IL-2) regulates the accessibility of the IL-2-responsive enhancer in the IL-2 receptor alpha gene to transcription factors.
Rusterholz C, Henrioud PC, Nabholz M (1999) Interleukin-2 (IL-2) regulates the accessibility of the IL-2-responsive enhancer in the IL-2 receptor alpha gene to transcription factors. Mol Cell Biol 19(4):2681-2689. doi: 10.1128/mcb.19.4.2681 PMID: 10082534
Related Products: CD25 Rat Monoclonal (Cat. #AB-19)
Cognitive functions of the basal forebrain.
Baxter M, Chiba A (1999) Cognitive functions of the basal forebrain. Curr Opin Neurobiol 9:178-183. doi: 10.1016/s0959-4388(99)80024-5
Objective: To recent studies of the role of the basal forebrain cholinergic neurons in attention, memory, and cortical information processing, focusing primarily on experiments using the selective cholinergic immunolesion method.
Related Products: 192-IgG-SAP (Cat. #IT-01)
See Also:
- McGaughy J et al. Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behav Neurosci 110:247-265, 1996.
- Waite JJ et al. Deficit in selective and divided attention associated with cholinergic basal forebrain immunotoxic lesion produced by 192-Saporin; motoric/sensory deficit associated with Purkinje cell immunotoxic lesion produced by OX7-Saporin. Neurobiol Learn Mem 71(3):325-352, 1999.
Lesion of septal-hippocampal neurons with 192 IgG-saporin alters function of M1 muscarinic receptors.
Potter PE, Gaughan C, Assouline Y (1999) Lesion of septal-hippocampal neurons with 192 IgG-saporin alters function of M1 muscarinic receptors. Neuropharmacol 38:579-586. doi: 10.1016/s0028-3908(98)00207-x
Related Products: 192-IgG-SAP (Cat. #IT-01)
Cerebrospinal fluid cholinesterases–markers for loss of cholinergic basal forebrain neurons?
Rossner S, Bakinde N, Zeitschel U, Schliebs R, Bigl V (1999) Cerebrospinal fluid cholinesterases–markers for loss of cholinergic basal forebrain neurons?. Int J Dev Neurosci 16(7-8):669-673. doi: 10.1016/s0736-5748(98)00077-x
Related Products: 192-IgG-SAP (Cat. #IT-01)
Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies.
Koshiba M, Rosin DL, Hayashi N, Linden J, Sitkovsky MV (1999) Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies. Mol Pharmacol 55(3):614-624. PMID: 10051547
Related Products: Antibody to Adenosine Receptor A2A (7F6-G5-A2) (Cat. #AB-V58)
Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing.
Martin WJ, Gupta NK, Loo CM, Rohde DS, Basbaum AI (1999) Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing. Pain 80:57-65. doi: 10.1016/s0304-3959(98)00194-8
Summary: The authors used Anti-DBH-SAP to re-examine the contribution of noradrenergic pathways to nociception and to morphine analgesia. They also evaluated morphine analgesia in the formalin test and found that toxin-treated animals exhibited enhanced morphine analgesia. These results establish the utility of using this immunotoxin to selectively destroy subpopulations of noradrenergic cell groups and provide evidence that acute and persistent nociception are differentially regulated by descending noradrenergic pathways.
Usage: Intrathecal treatment with Anti-DBH-SAP attenuates formalin pain (5.0 µg/20 µl).
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Selective immunotoxin-induced cholinergic deafferentation alters blood flow distribution in the cerebral cortex.
Waite JJ, Holschneider DP, Scremin OU (1999) Selective immunotoxin-induced cholinergic deafferentation alters blood flow distribution in the cerebral cortex. Brain Res 818:1-11. doi: 10.1016/s0006-8993(98)01174-3
Related Products: 192-IgG-SAP (Cat. #IT-01)