The A2A adenosine receptor (ADORA2A) is a G protein-coupled receptor whose activity is mediated through G protein–dependent activation of adenylyl cyclase. It is widely expressed in the basal ganglia, vasculature, T lymphocytes, and platelets. A2A receptor signaling can suppress immune cell activity, providing protection against tissue inflammation, and may regulate myocardial oxygen demand and coronary blood flow through vasodilation. Its presence in the brain has also made it a target of interest in studies and potential treatments for insomnia, pain, depression, and Parkinson’s disease.
