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Targeting serotonin re-uptake transporter (SERT) -expressing cells with a monoclonal antibody to an epitope from the extracellular domain of SERT: Results with a saporin conjugate.
Lappi D, Kohls M, Majer K, Russell B, Blakely R Richerson G (2002) Targeting serotonin re-uptake transporter (SERT) -expressing cells with a monoclonal antibody to an epitope from the extracellular domain of SERT: Results with a saporin conjugate. FENS 2002 Abstracts 049.7. Federation of European Neuroscience Societies, Paris, France. PMID: 0
Related Products: Antibody to Serotonin Transporter (SERT, Cat. #AB-N09), Anti-SERT-SAP (Cat. #IT-23)
Effects of mice EGF-responsive neural stem cells grafts and fetal septal cells grafts implanted into the dorsal hippocampus of rats after immunotoxic denervation
Jeltsch H, Aloy E, Schimchowitsch S, Caillard S, Mohier E Cassel JC (2002) Effects of mice EGF-responsive neural stem cells grafts and fetal septal cells grafts implanted into the dorsal hippocampus of rats after immunotoxic denervation. FENS 2002 Abstracts 141.13. Federation of European Neuroscience Societies, Paris, France.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Selective lesioning of the developing cholinergic and noradrenergic systems: Anatomical, neurochemical and functional effects
Leanza G, Cataudella T (2002) Selective lesioning of the developing cholinergic and noradrenergic systems: Anatomical, neurochemical and functional effects. FENS 2002 Abstracts 151.12. Federation of European Neuroscience Societies, Paris, France.
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Selective neonatal lesions of the basal forebrain cholinergic neurons impair memory of socially-transmitted food preferences in adult rats
Ricceri L, Moles A, Scattoni ML, Calamandrei G (2002) Selective neonatal lesions of the basal forebrain cholinergic neurons impair memory of socially-transmitted food preferences in adult rats. FENS 2002 Abstracts 209.4. Federation of European Neuroscience Societies, Paris, France.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Impairment and restoration of spatial abilities following 192 IgG-saporin or quisqualic acid lesions of the median septum in rats
Brandner C (2002) Impairment and restoration of spatial abilities following 192 IgG-saporin or quisqualic acid lesions of the median septum in rats. FENS 2002 Abstracts 210.3. Federation of European Neuroscience Societies, Paris, France.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Short and long term-effects on the serotonergic system of a selective cholinergic lesion in rats.
Ramirez MJ, Garcia-Alloza M, Lasheras B (2002) Short and long term-effects on the serotonergic system of a selective cholinergic lesion in rats. FENS 2002 Abstracts 010.16. Federation of European Neuroscience Societies, Paris, France.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm.
Johnson DA, Zambon NJ, Gibbs RB (2002) Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm. Brain Res 943(1):132-141. doi: 10.1016/s0006-8993(02)02623-9
Summary: The authors investigated the effects of selective cholinergic depletion in the medial septum on a spatial memory (DMP) task. Direct infusion of 0.22 or 1.0 µg 192-Saporin (Cat. #IT-01) produced a near complete depletion of cholinesterase-positive neurons for either dose. The DMP task provides a sensitive behavioral assay for deficits in cholinergic projections.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Combined 192 IgG-saporin and 5,7-dihydroxytryptamine lesions in the male rat brain: A neurochemical and behavioral study.
Lehmann O, Jeltsch H, Lazarus C, Tritschler L, Bertrand F, Cassel JC (2002) Combined 192 IgG-saporin and 5,7-dihydroxytryptamine lesions in the male rat brain: A neurochemical and behavioral study. Pharmacol Biochem Behav 72(4):899-912. doi: 10.1016/s0091-3057(02)00752-9
Summary: Female rats treated with both 192-Saporin (Cat #IT-01) and 5,7-DHT exhibited working memory impairments that were not seen with either treatment alone. For this paper, male rats were treated with 5,7-DHT and 1 µg per ventricle of 192-Saporin. While each compound produced a unique combination of effects, cognitive performance was only affected by treatment with both agents. These data indicate that interaction between the cholinergic and serotonergic mechanisms plays a role in cognitive functions for both sexes.
Usage: Injections of 1 µg per ventricle of 192-Saporin (Cat. #IT-01).
Related Products: 192-IgG-SAP (Cat. #IT-01)
5,7-DHT-induced hippocampal 5-HT depletion attenuates behavioural deficits produced by 192 IgG-saporin lesions of septal cholinergic neurons in the rat.
Lehmann O, Bertrand F, Jeltsch H, Morer M, Lazarus C, Will B, Cassel JC (2002) 5,7-DHT-induced hippocampal 5-HT depletion attenuates behavioural deficits produced by 192 IgG-saporin lesions of septal cholinergic neurons in the rat. Eur J Neurosci 15(12):1991-2006. doi: 10.1046/j.1460-9568.2002.02037.x
Summary: Although past data has shown that the cholinergic system of the basal forebrain is intrinsic to learning and memory, more recent data suggests that other neurotransmitter systems are also involved, perhaps serving modulatory functions. The authors used 5,7-DHT injections alone or with intraseptal 192-Saporin (Cat #IT-01, 0.4 µg/side) injections in rats. The results demonstrate that serotonergic denervation of the hippocampus attenuates deficits produced by a cholinergic denervation of the septal region of the basal forebrain.
Usage: The authors used 192-Saporin, 0.4 µg/side intraseptal (Cat. #IT-01).
Related Products: 192-IgG-SAP (Cat. #IT-01)
Unilateral lesions of the cholinergic Basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys.
Easton A, Ridley RM, Baker HF, Gaffan D (2002) Unilateral lesions of the cholinergic Basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys. Cereb Cortex 12(7):729-736. doi: 10.1093/cercor/12.7.729
Summary: The authors used a combination of basal forebrain lesioning using ME20.4-SAP (Cat. #IT-15) and surgery to isolate the inferior temporal cortex and medial temporal cortex from cholinergic afferents in rhesus monkeys. Testing of the treated animals demonstrated severe impairments in learning visual scenes and object-reward associations.
Related Products: ME20.4-SAP (Cat. #IT-15)