Bajo V, Leach N, Cordery P, Nodal F, King A (2014) The cholinergic basal forebrain in the ferret and its inputs to the auditory cortex. Eur J Neurosci 40:2922-2940. doi: 10.1111/ejn.12653 PMID: 24945075

Summary: The ferret has become a more common animal model in auditory neuroscience. Unlike rodent models, however, anatomical data describing the organization of the basal forebrain cholinergic system and its projections to the auditory cortex have not been well characterized. Using a variety of methods the authors mapped the architecture of the ferret basal forebrain. IHC was done with several antibodies including anti-ChAT (Cat. #AB-N34AP; 1:1000) and anti-NGFr (Cat. #AB-N07; 1:500). Animals also received 17 μg of ME20.4-SAP (Cat. #IT-15) in a total of 17 injections into the ectosylvian gyrus. The results indicate that acetylcholine is most likely involved in modulation of auditory processing.

Related Products: Choline Acetyltransferase Rabbit Polyclonal, affinity-purified (Cat. #AB-N34AP), NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07), ME20.4-SAP (Cat. #IT-15)

Gibbons DD, Southerland EM, Hoover DB, Beaumont E, Armour JA, Ardell JL (2012) Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias. Am J Physiol Regul Integr Comp Physiol 302(3):R357-R364. doi: 10.1152/ajpregu.00535.2011 PMID: 22088304

Summary: Cardiac arrhythmias can be generated by excessive activation of specific inputs to the intrinsic cardiac nervous system. The authors sought to determine whether subpopulations of neurons were responsible for this activation, and therefore potential therapeutic targets. A series of studies were done following electrical stimuli to the mediastinal nerves. Choline acetyltransferase levels were assessed using anti-ChAT (Cat. #AB-N34) in immunohistochemistry. The data suggest activation of certain neurons by mediastinal nerve stimulation results in atrial arrhythmias leading to atrial fibrillation.

Related Products: Choline Acetyltransferase Rabbit Polyclonal (Cat. #AB-N34)

Benecke S, Ostermann-Latif C, Mader M, Schmidt B, Unger JW, Westarp ME, Felgenhauer K (1993) Antibodies raised against synthetic peptides react with choline acetyltransferase in various immunoassays and in immunohistochemistry. J Neurochem 61(3):804-811. doi: 10.1111/j.1471-4159.1993.tb03590.x PMID: 8360685

Related Products: Choline Acetyltransferase Rabbit Polyclonal (Cat. #AB-N34), Choline Acetyltransferase Rabbit Polyclonal, affinity-purified (Cat. #AB-N34AP)