Avrampou K, Pryce KD, Ramakrishnan A, Sakloth F, Gaspari S, Serafini RA, Mitsi V, Polizu C, Swartz C, Ligas B, Richards A, Shen L, Carr FB, Zachariou V (2019) RGS4 maintains chronic pain symptoms in rodent models. J Neurosci 39(42):8291-8304. doi: 10.1523/JNEUROSCI.3154-18.2019 PMID: 31308097

Usage: western

Related Products: Metabotropic Glutamate Receptor 2 (mGluR2) Mouse Monoclonal (Cat. #AB-N32)

Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R (2019) Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses. FASEB J 33(12):13734-13746. doi: 10.1096/fj.201901543R PMID: 31585509

Usage: immunohistochemistry (1:150)

Related Products: Metabotropic Glutamate Receptor 2 (mGluR2) Mouse Monoclonal (Cat. #AB-N32)

Sabbah S, Papendorp C, Koplas E, Beltoja M, Etebari C, Gunesch AN, Carrete L, Kim MT, Manoff G, Bhatia-Lin A, Zhao T, Schreck D, Dowling H, Briggman KL, Berson DM (2018) Synaptic circuits for irradiance coding by intrinsically photosensitive retinal ganglion cells. bioRxiv 442954. doi: 10.1101/442954

Objective: To explore the synaptic networks responsible for the unique capacity of intrinsically photosensitive retinal ganglion cells (ipRGCs) to encode overall light intensity. This luminance signal is crucial for circadian, pupillary and related reflexive responses light.

Summary: Most ipRGCs sample from all bipolar terminals costratifying with their dendrites, but M1 cells avoid all OFF bipolar input and accept only ectopic ribbon synapses from ON cone bipolar axonal shafts. These monad synapses are equipped with as many as a dozen ribbons and only one postsynaptic process.

Usage: Immunohistochemistry of retina – after recording, retinas were fixed and counterstained with rabbit anti-melanopsin (1:1000) to enhance the fluorescence of the GFP-based GCaMP6f indicator.

Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38), Metabotropic Glutamate Receptor 2 (mGluR2) Mouse Monoclonal (Cat. #AB-N32)

Kamath SP, Chen AI (2018) Myocyte enhancer factor 2c regulates dendritic complexity and connectivity of cerebellar Purkinje cells. Mol Neurobiol 56:4102–4119. doi: 10.1007/s12035-018-1363-7 PMID: 30276662

Objective: To investigate the roles of Mef2c in cerebellar Purkinje cells during the first three weeks of postnatal development.

Summary: Mef2c haploinsufficiency is implicated in behavioral deficits related to autism, schizophrenia, and intellectual disability.  Results reveal the specific expression and functional relevance of Mef2c in developing Purkinje cells and offer insight to how disruption of the expression of Mef2c in a GABAergic neuronal subtype may lead to pathogenesis of cerebellar-associated disorders.

Usage: Immunohistochemistry – mouse anti-mGluR2 (1:1500)

Related Products: Metabotropic Glutamate Receptor 2 (mGluR2) Mouse Monoclonal (Cat. #AB-N32)

Yin S, Noetzel MJ, Johnson KA, Zamorano R, Jalan-Sakrikar N, Gregory KJ, Conn PJ, Niswender CM (2014) Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34(1):79-94. doi: 10.1523/JNEUROSCI.1129-13.2014 PMID: 24381270

Summary: The eight mGlu receptor subtypes that have been discovered have been thought to function only as homodimers. Although recent studies have suggested that these receptors can form heterodimers in vitro, this has not been demonstrated in vivo. Using a variety of methods, including western blots, coimmunoprecipitation, thallium flux assays, transient transfections, and whole cell patch recordings the authors show that mGlu2 and mGlu4 form a hetero-complex in both rat and mouse tissues. An anti-mGluR2 (Cat. #AB-N32) was used in coimmunoprecipitation.

Related Products: Metabotropic Glutamate Receptor 2 (mGluR2) Mouse Monoclonal (Cat. #AB-N32)

Chen AI, Nguyen CN, Copenhagen DR, Badurek S, Minichiello L, Ranscht B, Reichardt LF (2011) TrkB (Tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex. J Neurosci 31(8):2769-2780. doi: 10.1523/JNEUROSCI.4991-10.2011 PMID: 21414899

Summary: In this work the authors investigated the role of TrkB in GABAergic inhibitory synapses in the mouse cerebellar cortex. Using a variety of techniques, including immunohistochemistry utilizing an mGluR2 antibody (Cat. #AB-N32), it was shown that TrkB is required for both assembly and maintenance of these synapses. The primary role of TrkB appears to be regulating the localization of synaptic constituents.

Related Products: Metabotropic Glutamate Receptor 2 (mGluR2) Mouse Monoclonal (Cat. #AB-N32)

Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N (1996) Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations of Golgi cells in the rat cerebellum. Neuroscience 75(3):815-826. doi: 10.1016/0306-4522(96)00316-8 PMID: 8951875

Related Products: Metabotropic Glutamate Receptor 2 (mGluR2) Mouse Monoclonal (Cat. #AB-N32)

Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N (1996) Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: an immunohistochemical study with a monoclonal antibody. Neurosci Lett 202(3):197-200. doi: 10.1016/0304-3940(95)12248-6 PMID: 8848265

Related Products: Metabotropic Glutamate Receptor 2 (mGluR2) Mouse Monoclonal (Cat. #AB-N32)