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  4. Brainstem pre-sympathetic neurons contribute to irregular breathing patterns in volume overload heart failure.

Brainstem pre-sympathetic neurons contribute to irregular breathing patterns in volume overload heart failure.

Toledo C, Andrade DC, Del Rio R (2019) Brainstem pre-sympathetic neurons contribute to irregular breathing patterns in volume overload heart failure. FASEB J 33(1):lb630. Experimental Biology 2019 Meeting Abstracts doi: 10.1096/fasebj.2019.33.1_supplement.lb630

Objective: To investigate the contribution of RVLM-C1 neurons on breathing disorders in chronic heart failure (CHF).

Summary: RVLM-C1 neurons play a critical role in the maintenance of altered breathing patterns in CHF rats and highlighted their contribution to the worsening of cardiac function during central chemoreflex activation. DBH-SAP treatment decreased active expiration in CHF rats and deleterious effects of central chemoreflex activation on diastolic cardiac function and cardiac autonomic control were blunted.

Usage: Stereotaxic bilateral injections of Anti-DBH-SAP (5 ng/150 nl).

Related Products: Anti-DBH-SAP (Cat. #IT-03)