Ohtori S, Inoue G, Koshi T, Ito T, Doya H, Moriya H, Takahashi K (2006) Substance P-saporin down-regulates substance P receptor immunoreactive sensory dorsal root ganglion neurons innervating the lumbar intervertebral discs in rats. Spine 31:2987-2991. doi: 10.1097/01.brs.0000250306.12996.fa
Summary: Neurokinin-1 (NK-1) receptor expressing neurons that innervate lumbar intervertebral discs may be involved in lower back pain. Here the authors investigate the basic effect of SP-SAP (Cat. #IT-07) on neurons innervating the L5/6 intervertebral disc. Rats were injected with 175 ng of SP-SAP. The number of NK-1 receptor expressing neurons was reduced by over 75% in the treated animals, demonstrating SP-SAP as a useful tool to investigate the mechanism of discogenic low back pain, particulary for investigating behavioral impacts.
Related Products: SP-SAP (Cat. #IT-07)