Staib JM, Della Valle R, Knox DK (2018) Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory. Learn Mem 152:71-79. doi: 10.1016/j.nlm.2018.05.009
Objective: To determine which efferent projections are critical for contextual fear memory discrimination and extinction memory.
Summary: The results of this study suggest that MS/vDBB cholinergic neurons are critical for fear and extinction memory.
Usage: 192-IgG saporin was infused into all brain regions at a concentration of 0.2 μg/μL dissolved in 0.2 M PBS. The total volume of each injection was 0.5 μL. Sham surgeries were accomplished using the same volume (0.5 μL) of PBS.
Related Products: 192-IgG-SAP (Cat. #IT-01)