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Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus.

Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus.

Khasabov SG, Ghilardi JR, Mantyh PW, Simone DA (2005) Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus. J Neurophysiol 93(2):998-1006. doi: 10.1152/jn.01160.2003

Summary: The involvement of neurokinin-1 receptor-expressing neurons in the spinal cord with the ascending systems of hyperalgesia and central sensitization has been well established. The authors used 10 µl injections of 5 µM SP-SAP (Cat. #IT-07) into the intrathecal space of rats, and examined the descending systems that travel via the dorsolateral funiculus (DLF). While SP-SAP alone had no effect, administration of SP-SAP in conjunction with a DLF transection enhanced neuronal responses to mechanical and heat stimuli.