Wenninger JM, Pan LG, Klum L, Leekley T, Bastastic J, Hodges MR, Feroah TR, Davis S, Forster HV (2004) Large lesions in the pre-Botzinger complex area eliminate eupneic respiratory rhythm in awake goats. J Appl Physiol 97(5):1629-1636. doi: 10.1152/japplphysiol.00953.2003
Summary: Previously the authors demonstrated that lesioning the pre-Bötzinger Complex (pre-BötzC) with SP-SAP (Cat. #IT-07) resulted in transient disruptions of normal respiratory muscle activation in goats. The purpose of this study was to examine the effects of a more complete lesion of the pre-BötzC area. The authors treated SP-SAP-lesioned goats with ibotenic acid. The results suggest that the pre-BötzC is critical for generating a normal respiratory rhythm during the awake state.
Related Products: SP-SAP (Cat. #IT-07)