Helm KA, Ziegler DR, Gallagher M (2004) Habituation to stress and dexamethasone suppression in rats with selective basal forebrain cholinergic lesions. Hippocampus 14(5):628-635. doi: 10.1002/hipo.10203
Summary: Basal forebrain cholinergic neurons may be involved in hippocampal and medial prefrontal cortex inhibition of glucocorticoid stress responses. The authors investigated the effects of 0.05 to 0.075 µg injections of 192-Saporin (Cat. #IT-01) into the medial septum/vertical limb of the diagonal band of rats by measuring corticosterone levels during a restraint stress test. Lesioned rats displayed less stress suppression on the administration of dexamethasone than controls, indicating that cholinergic neurons are involved in these stress responses.
Related Products: 192-IgG-SAP (Cat. #IT-01)