Chang Q, Gold PE (2004) Impaired and spared cholinergic functions in the hippocampus after lesions of the medial septum/vertical limb of the diagonal band with 192 IgG-saporin. Hippocampus 14(2):170-179. doi: 10.1002/hipo.10160
Summary: 192-Saporin has been widely used to eliminate cholinergic neurons in the basal forebrain. These lesions can produce near-total loss of choline acetyltranferase (ChAT)-positive neurons in the medial septum/vertical limb of the diagonal band of Broca (MS/VDB). There is evidence that this ChAT deficit produces an upregulation of cholinergic mechanisms providing input to the hippocampus. Using either 0.2 or 0.3 µl of 0.5 µg/µl 192-Saporin (Cat. #IT-01) injected into the MS/VDB the authors examined the residual release of acetylcholine in the hippocampus after lesioning.
Related Products: 192-IgG-SAP (Cat. #IT-01)