Smith JE, Co C, Yin X, Sizemore GM, Liguori A, Johnson WE 3rd, Martin TJ (2004) Involvement of cholinergic neuronal systems in intravenous cocaine self-administration. Neurosci Biobehav Rev 27(8):841-850. doi: 10.1016/j.neubiorev.2003.11.002
Summary: Recent studies have demonstrated that cholinergic neurons take part in the process of cocaine self-administration. In this study the authors used 0.25 µg-injections of 192-Saporin (Cat. #IT-01) into the posterior nucleus accumbens (Nacc)-ventral pallidum (VP) region of rats to identify specific subsets of cholinergic neurons that are involved. The results indicate that cholinergic innervations of the VP, the medial septum/diagonal band of Broca, and the Nacc are inhibitory to the underlying processes of cocaine self-administration.
Related Products: 192-IgG-SAP (Cat. #IT-01)