Vuckovich JA, Semel ME, Baxter MG (2004) Extensive lesions of cholinergic basal forebrain neurons do not impair spatial working memory. Learn Mem 11:87-94. doi: 10.1101/lm.63504
Summary: The authors wished to examine whether cerebellar Purkinje cells damaged during a cholinergic basal forebrain lesion might be the cause of impaired working memory. Four injections of 0.2-0.3 µl (0.12-0.15 µg/ml, 192-Saporin, Cat. #IT-01) into the medial septum/vertical limb of the diagonal band, two injections into the horizontal limb of the diagonal band of Broca, and four injections into the nucleus basalis magnocellularis/ substantia innominata of rats were used to produce a very specific lesion. The results indicate that the cholinergic basal forebrain does not play a substantial role in spatial working memory.
Related Products: 192-IgG-SAP (Cat. #IT-01)