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Increased calcium influx and ribosomal content correlate with resistance to endoplasmic reticulum stress-induced cell death in mutant leukemia cell lines.

Increased calcium influx and ribosomal content correlate with resistance to endoplasmic reticulum stress-induced cell death in mutant leukemia cell lines.

Zhang Y, Berger SA (2004) Increased calcium influx and ribosomal content correlate with resistance to endoplasmic reticulum stress-induced cell death in mutant leukemia cell lines. J Biol Chem 279(8):6507-6516. doi: 10.1074/jbc.M306117200

Summary: Ca2+ plays a vital role in many cell processes. To investigate events associated with Ca2+ and endoplasmic reticulum (ER) stress-induced cell death, the authors developed a mutant cell line with resistance to several ER stress-inducing agents. One of the assays used to define the characteristics of this cell line was treatment of the cells with 3 µg/ml of Saporin (Cat. #PR-01) and subsequent analysis of protein expression. The suppression of ribosome function partially reversed the resistance to ER stress-induced cell death.