Winters BD, Robbins TW, Everitt BJ (2004) Selective cholinergic denervation of the cingulate cortex impairs the acquisition and performance of a conditional visual discrimination in rats. Eur J Neurosci 19(2):490-496. doi: 10.1111/j.0953-816x.2003.03157.x
Summary: Performance in conditional discrimination tasks is thought to be controlled at least in part by the cingulate cortex and its basal forebrain afferents. Using bilateral 0.5 µl injections of 0.02 µg/ml 192-Saporin (Cat. #IT-01) into the cingulate cortex of rats, the authors investigated the role of cholinergic projections from the vertical limb nucleus of the diagonal band to the cingulate cortex in specific types of learning. The results reinforce the idea that cholinergic projections to the cortex are involved in processing sensory information as well as task-related stimuli.
Related Products: 192-IgG-SAP (Cat. #IT-01)