Chudasama Y, Dalley JW, Nathwani F, Bouger P, Robbins TW (2004) Cholinergic modulation of visual attention and working memory: Dissociable effects of basal forebrain 192-IgG-saporin lesions and intraprefrontal infusions of scopolamine. Learn Mem 11(1):78-86. doi: 10.1101/lm.70904
Summary: It is hypothesized that cortical cholinergic dysfunction underlies the cognitive impairments associated with dementia and normal aging. The authors examined the role of these neurons in both attentional and mnemonic functions, using either bilateral infusions of 125 ng of 192-Saporin (Cat. #IT-01) into the bregma of rats or infusions of scopolamine. The results suggest that attentional and working memory capacities can be tested separately during the same session. It is also indicated that the CBF system is a modulator of both attentional and mnemonic processing.
Related Products: 192-IgG-SAP (Cat. #IT-01)