Harmon KM, Wellman CL (2003) Differential effects of cholinergic lesions on dendritic spines in frontal cortex of young adult and aging rats. Brain Res 992:60-68. doi: 10.1016/j.brainres.2003.08.029
Summary: The authors used 0.15 µg of 192-Saporin (Cat. #IT-01) injected into the nucleus basalis magnocellularis of rats to study whether dendritic spine density is altered by cholinergic deafferentation. While the spine density decreased in young rats, middle-aged and aged animals did not display a density significantly different than controls.
Related Products: 192-IgG-SAP (Cat. #IT-01)