Vierck CJ, Kline RH, Wiley RG (2003) Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli. Neuroscience 119(1):223-232. doi: 10.1016/s0306-4522(03)00125-8
Summary: Administration of SP-SAP (Cat. #IT-07) eliminates sensitization of nocifensive reflexes. The authors investigate whether SP-SAP elimination of neurokinin-1 receptor-expressing neurons in the lumbar spinal cord affects nociceptive sensitivity in general, or preferentially affects nociception dependent on spinal and brainstem, or cerebral processing. Rats treated with spinal intrathecal injections of 175 ng of SP-SAP showed attenuated thermal hyperalgesia, and no secondary hyperalgesia, while innate reflexes were unaffected by SP-SAP treatment.
Related Products: SP-SAP (Cat. #IT-07)