Riley J, Lin LH, Chianca DA, Talman WT (2002) Ablation of NK1 receptors in rat nucleus tractus solitarii blocks baroreflexes. Hypertension 40(6):823-826. doi: 10.1161/01.hyp.0000042089.34004.cf
Summary: Stimulation of arterial baroreflexes releases the neuropeptide substance P (SP) from vagal afferent nerves within the nucleus tractus solitarii. To ascertain whether the neurons taking up this SP are critical to baroreflex transmission, the authors injected 18 ng SP-SAP (Cat. #IT-07) into the nucleus tractus solitarii of rats. In animals that received bilateral injections, baroreflex gain was significantly reduced, indicating that neurons expressing SP receptors play a critical role in mediation of this process.
Related Products: SP-SAP (Cat. #IT-07)