Nattie EE, Li A (2002) Substance P-saporin lesion of neurons with NK1 receptors in one chemoreceptor site in rats decreases ventilation and chemosensitivity. J Physiol 544(Pt 2):603-616. doi: 10.1113/jphysiol.2002.020032
Summary: The authors injected 0.1 pmol SP-SAP (Cat. #IT-07) into the retrotrapezoid nucleus/parapyramidal region of rats. The lesioned animals demonstrated hypoventilation while at rest, decreased response to high CO2 levels, and a tendency to sleep less.
Related Products: SP-SAP (Cat. #IT-07)