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Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure.

Andrade DC, Toledo C, Díaz HS, Lucero C, Arce-Álvarez A, Oliveira LM, Takakura AC, Moreira TS, Schultz HD, Marcus NJ, Alcayaga J, Del Rio R (2019) Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure. Clin Sci (Lond) 133(3):393-405. doi: 10.1042/CS20180589

Objective: To determine the role played by RVLM-C1 neurons in cardiac autonomic imbalance, arrhythmogenesis and cardiac dysfunction in volume overload-induced heart failure.

Summary: RVLM-C1 neurons were selectively ablated using Anti-DBH-SAP and measures of cardiacautonomictone, function, and arrhythmia incidence were evaluated. Cardiac autonomic imbalance, arrhythmogenesis and cardiac dysfunction were present in HF rats and improved after Anti-DBH-SAP treatment.

Usage: 7.5ng/100nl of sterile saline solution was injected bilaterally into the RVLM.

Related Products: Anti-DBH-SAP (Cat. #IT-03)