Zhang YW, Jia WX, Wang YQ, Zhou P, Zhang XY, Liu CW, Wang J, Lu XF, Dai CF (2026) Cerebrospinal fluid-contacting nucleus mediates the balance of depth during general anesthesia in mice. Neuropharmacology 111037. doi: 10.1016/j.neuropharm.2026.111037 PMID: 42214455
Objective: To investigate the role of the cerebrospinal fluid-contacting nucleus (CSF-CN), which directly interfaces with the CSF, in modulating general anesthesia in mice
Summary: The authors found that the CSF-CN plays a critical homeostatic role in general anesthesia. During deep anesthesia, it may buffer excessive anesthetic inhibition, whereas during emergence, it regulates the recovery process to prevent premature or overly rapid awakening.
Usage: CSF-CN was labeled by administering the retrograde tracer cholera toxin subunit B-594 into the lateral ventricle, and it was selectively ablated using a conjugate of saporin and cholera toxin subunit B.
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