Keilholz A, Ahmadzadeh E, Cornelius-Green J, Osman K, Smith C, Cummings K, Lever T, Nichols N (2026) Modulation of orexinergic neurons in the perifornical region of the hypothalamus impacts tongue motility and hypoglossal motor output in an inducible rodent model of hypoglossal motor neuron degeneration. American Physiology Summit 41(S1) doi: 10.1152/physiol.2026.41.S1.2300706
Objective: To examine role of orexinergic neurons in the perifornical region of the hypothalamus (PeF) project to the XII nucleus in treatment for patients with motor neuron diseases such as amyotrophic lateral sclerosis (ALS).
Summary: Aerobic and limb-based exercise has been shown to increase brain derived neurotrophic factor (BDNF) and orexinergic (OX) expression, which improved functional outcomes in ALS patients and rodent models. Results suggest that perifornical region of the hypothalamus (PeF) OX neurons promote XII plasticity to improve XII axis function following XII LMN loss.
Usage: Rodent model using intralingual injection in adult male rats with CTB-SAP (IT-14)
Related Products: CTB-SAP (Cat. #IT-14)