Konturek-Ciesla A (2023) Aging hematopoiesis: Functional insights and prospects for rejuvenation. Lund University Thesis.
Objective: To examine the function of hematopoietic stem cells (HSCs), the source of all mature blood cells, during adulthood and upon aging.
Summary: A gradual decrease in HSCs multi-lineage differentiation capacity, with the most significant reduction in their lymphoid output. The decreased lymphopoiesis could be attributed to the lymphoid progenitor subset, MPP Ly-I, revealing defects in the HSCs transition to these cells. Hematopoietic rejuvenation techniques studied through HSCs and their aging processes.
Usage: Anti-CD45-SAP (IT-91) was delivered to ex vivo HSCs cells.
Related Products: Anti-CD45.2-SAP (Cat. #IT-91)