Wei J, Liu H, Zhou F, Zhang H, Zhang L (2024) The recent research progress in neurobiological characteristics and pain regulation of the cerebrospinal fluid-contacting nucleus. Anesthesiology and Perioperative Science 2(17) doi: 10.1007/s44254-024-00051-9
Objective: To provide novel insights into the investigation of pain regulation within bidirectional regulatory pathway between the brain and cerebrospinal fluid, with a specific focus one elucidating the role of the CSF-contacting nucleus as a bridge structure.
Summary: Studies revealed that the targeted destruction of the CSF-contacting nucleus and reduction in the basic pain threshold were achieved by introducing CB-saporin (SAP) into the lateral ventricle, thereby facilitating the pain behavior response in the pain model.
Related Products: CTB-SAP (Cat. #IT-14)
See Also:
- Liu H et al. Role of the cerebrospinal fluid-contacting nucleus in the descending inhibition of spinal pain transmission. Exp Neurol 261:475-485, 2014.
- Cao J et al. [Targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-HT and c-Fos in spinal dorsal horn of rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi 30:218-222, 2014.