Kelly SC, McKay EC, Beck JS, Collier TJ, Dorrance AM, Counts SE (2019) Locus coeruleus degeneration induces forebrain vascular pathology in a transgenic rat model of alzheimer’s disease. J Alzheimers Dis 70(2):371-388. doi: 10.3233/JAD-190090 PMID: 31177220
Objective: To understand the extent to which locus coeruleus projection system degeneration influences vascular pathology.
Summary: Noradrenergic locus coeruleus (LC) neuron loss is a significant feature of mild cognitive impairment and Alzheimer’s disease (AD). The authors stereotactically lesioned LC projection neurons innervating the prefrontal cortex of six-month-old Tg344–19 AD rats using DBH-SAP, or an untargeted control IgG-SAP. DBH-sap-lesioned animals performed significantly worse than IgG-sap animals on the Barnes maze task in measures of both spatial and working memory. DBH-sap-lesioned rats also displayed increased amyloid and inflammation pathology compared to IgG-sap controls. Results indicate that LC projection system degeneration is a nexus lesion that compromises both vascular and neuronal function in cognitive brain areas during the prodromal stages of AD.
Usage: Anti-DBH-SAP (IT-03) or control Mouse IgG-sap (IT-18) were administered to the PFC bilaterally ( 2.5 μg/injection).
Related Products: Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18)