Makarova AO, Kostenk VV, Ovsyanikova OV, Svirshchevskaya EV, Lutsenko GV, Lutsenko AM (2023) Heat shock proteins on tumor cell surface as target for anti-tumor therapy (a review). Russian Journal of Bioorganic Chemistry 50(3):644-656. doi: 10.1134/S1068162024030038
Objective: To present the characteristics of the main proteins of the heat shock proteins (HSP) family, the features of their expression in tumor cells, and the possibility of using monoclonal antibodies against these proteins as a guiding vector for anti-tumor immunotherapy.
Summary: Apart from targeted delivery of NPs and different therapeutic drugs into cancer cells, another advantage of mAbs against HSP70 is their ability to activate anti-tumor antibody-dependent cellular cytotoxicity.
Usage: Certain antitumor drugs can be delivered by mAbs not only as part of NPs, but also as a drug–antibody conjugate. For instance, anti-HSP65 mouse mAb ML30 conjugated to Saporin (PR-01) almost fully inhibited cell proliferation of cell lines U937 and Daudi that express HSP65 on their surfaces.
Related Products: Saporin (Cat. #PR-01), Custom Conjugates