Kiguchi N, Saika F, Fukazawa Y, Matsuzaki S, Kishioka S (2020) Critical role of GRP receptor-expressing neurons in the spinal transmission of imiquimod-induced psoriatic itch. Neuropsychopharmacol Rep 40(3):287-290. doi: 10.1002/npr2.12120 PMID: 32584520
Objective: To determine whether itch-responsive GRPR⁺ neurons in the spinal dorsal horn contribute to the transmission of imiquimod (IMQ)-induced psoriatic itch.
Summary: Topical IMQ induced psoriasis-like dermatitis and scratching behavior, accompanied by upregulation of GRP and GRPR mRNA in the spinal dorsal horn. Chemogenetic silencing of GRP⁺ neurons or ablation of GRPR⁺ neurons with Bombesin-SAP significantly reduced scratching, showing that the spinal GRP–GRPR pathway mediates psoriatic itch.
Usage: Bombesin-SAP (IT-40) was administered intrathecally at 250 ng in 5 µL phosphate-buffered saline to selectively ablate spinal GRPR⁺ neurons.
Related Products: Bombesin-SAP (Cat. #IT-40)