Handfield J (2025) Focal irradiation regulates distal neural stem and progenitor cell behaviour. Univ Toronto Thesis.
Objective: To investigate how focal irradiation (IR) impacts non-irradiated neural stem cell (NSC) niches along the neuraxis and whether microglia mediate these long-distance effects.
Summary: Focal cranial IR decreased spinal cord-derived NSCs, while spinal IR reduced neuroblasts and NSCs in the forebrain. Microglia ablation did not rescue these effects, suggesting IR alters NSC behavior along the neuraxis independently of microglia.
Usage: Mac-1-SAP (CD11b, Cat. #IT-06) was cited as a method previously used for microglia ablation.
Related Products: Mac-1-SAP mouse/human (Cat. #IT-06)
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