Brown TW, Vilallongue N, Hales SC, Srikanta S, Rochon PL, Rangel Olguin AG, Waxman SB, Tufford A, Van Prooijen J, Krishnaswamy A, Cermakian N, Cayouette M (2025) Retinal glia regulate development of the circadian photoentrainment circuit. Cell Rep 44(11):116464. doi: 10.1016/j.celrep.2025.116464 PMID: 41150857
Objective: To examine the role of Müller glia in the development of hypothalamus-projecting ipRGCs and their contribution to circadian photoentrainment.
Summary: Disrupting SNARE-mediated release in Müller glia reduced ATP secretion, heightened ipRGC light responses, and impaired photoentrainment without affecting vision or pupil reflexes. The study highlights a glia-dependent mechanism essential for proper maturation of the circadian visual pathway.
Usage: Anti-Melanopsin (AB-N38) was used for immunohistochemistry (IHC) at 1:100 dilution.
Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)