Kuroda M, Komatsu N, Kosai A, Hamakubo T, Abe T (2024) Anti-EGFR antibody immunotoxins improve cytotoxic effects in the salivary gland cancer A253 cell line. doi: 10.1016/j.ajoms.2024.11.003
Objective: To confirm the antitumor effects of IT-Cetuximab (IT-Cmab= saporin-conjugated anti-EGFR antibody), which is cetuximab conjugated with a toxin, targeting salivary gland cancers—a type of cancer with limited effective treatment options aside from surgery.
Summary: Cmab alone exhibited no cytotoxic effects, but IT-Cmab demonstrated concentration-dependent cytotoxic effects in A253 cells.
Usage: Cytotoxicity assay (@1.34pM to 4.2nM)
Related Products: Saporin (Cat. #PR-01)