Komatsu N, Komatsu M, Ohashi R, Horii A, Hoshi K, Takato T, Abe T, Hamakubo T (2020) Photosensitizer with illumination enhances in vivo antitumor effect of anti-robo1 immunotoxin on maxillary sinus squamous cell carcinoma. Anticancer Res 40(7):3792-3799. doi: 10.21873/anticanres.14368 PMID: 32620618
Objective: To focus on the axon guidance receptor roundabout guidance receptor 1 (ROBO1) as a target for monoclonal antibody therapy of Head and neck squamous cell carcinoma (HNSCC).
Summary: Pronounced anti-tumor effects were elicited by the administration of saporin-conjugated anti-Robo1 immunotoxin (IT-Robo1) and AlPcS2a with light illumination on tumor size and pathological characteristics. The results showed that photosensitizer treatment with illumination robustly enhanced the anti tumor effect of the IT-Robo1 immunotoxin.
Usage: IT-ROBO1 (16ug) was intraperitoneally administered to HSQ-89 xenografted mice.
Related Products: Saporin (Cat. #PR-01)