Spitale FM, Vicario N, Rosa MD, Tibullo D, Vecchio M, Gulino R, Parenti R (2020) Increased expression of connexin 43 in a mouse model of spinal motoneuronal loss. Aging (Albany NY) 12(13):12598-12608. doi: 10.18632/aging.103561 PMID: 32579130
Objective: To investigate the role of the main astroglial gap junctions (GJs)-forming connexin, Cx43, in human Amyotrophic lateral sclerosis (ALS) and the effects of focal spinal cord motoneuronal depletion onto the resident glial cells and Cx43 levels.
Summary: The data support the hypothesis that motoneuronal depletion may affect glial activity, which in turn results in reactive Cx43 expression, further promoting neuronal suffering and degeneration.
Usage: 12 μg of CTB-SAP injected into the left gastrocnemius muscle of mice to establish a model of spinal motoneuronal depletion.
Related Products: CTB-SAP (Cat. #IT-14)