Apps R, Strata P (2015) Neuronal circuits for fear and anxiety – the missing link. Nat Rev Neurosci 16(10):642. doi: 10.1038/nrn4028 PMID: 26333516
Objective: To study the active role of the cerebellar network in conditioned and unconditioned fear by quantifying the connection of cerebellar cortical areas to emotional driven responses.
Summary: The article seeks to quantify the connection of cerebellar cortical areas like the prefrontal cortex to emotional driven responses, like the freezing associated with fearful stimuli. CTB-SAP lesioned rats, causing localized cell death in the fear associated regions of the brain being studied, are compared to sham-lesioned rats and the length of freezing time as a response to a negatively-percevied auditory tone and cat-odor.
Usage: Rats received microinjections of the neurotoxin CTB–Saporin into the vermal lobule VIII which resulted in a localized lesion of cerebellar cortical connections.
Related Products: CTB-SAP (Cat. #IT-14)