Shivakumar AB, Mehak SF, Gangadharan G (2023) Medial-septal GABAergic neurons are essential for social memory in mice. Ann Neurosci 30(1 Suppl):YS2.5. doi: 10.1177/09727531231205772
Objective: To examine the role of septal GABAergic neurons in social memory
Summary: Authors used a novel immunotoxin, anti-vGAT-SAP (vesicular GABA transporters-saporin), to selectively lesion GABAergic neurons in the MS. Results indicate that septo-hippocampal GABAergic neuronal circuit is an important component of social memory. These results support the notion that inhibition/excitation imbalance in the hippocampus contributes to social deficits reminiscent of neuropsychiatric/neurodevelopmental disorders.
Related Products: Anti-vGAT-SAP (Cat. #IT-71)