Margeta M, Ohara PT, Bollen AW, Jasmin L (2004) Intrathecal application of saporin conjugates leads to development of pituitary adenomas in rats. J Neuropathol Exp Neurology 63(5):518.
Objective: To study the recovery from spinal cord demyelination or the effects of decreased central noradrenergic tone on pain behavior.
Summary: The spectrum of findings varied from small, sometimes multifocal nodules to large neoplasms that entirely replaced the normal gland and showed a significant degree of mitotic activity and nuclear pleomorphism. Development of this novel animal model will enable investigation of non-hormonal factors important in the pathogenesis of pituitary adenomas
Usage: Rats were injected intrathecally with CTB-SAP (IT-14) or to the anti-DBH-SAP (IT-03)
Related Products: CTB-SAP (Cat. #IT-14), Anti-DBH-SAP (Cat. #IT-03)