Shivakumar AB, Mehak SF, Gupta A, Gangadharan G (2024) Medial septal cholinergic neurotransmission is essential for social memory in mice. Prog Neuropsychopharmacol Biol Psychiatry 136:111207. doi: 10.1016/j.pnpbp.2024.111207 PMID: 39615870
Objective: To identify the physiological link between medial septal dependent cholinergic theta oscillations in the hippocampus and social memory behavior.
Summary: Selective ablation of cholinergic neurons in the medial septum (MS) impaired social memory in mice, while their sociability and social novelty remained intact. Additionally, these mice showed an attenuation of cholinergic theta oscillations (3–7Hz) in the hippocampal dorsal CA2 (dCA2) region. Furthermore, enhancing dCA2 theta oscillations by elevating cholinergic signaling using acetylcholinesterase inhibitor rescued social memory deficit. Together, these results indicate that 1) medial septal cholinergic neurons are essential for modulating social memory and 2) cholinergic hippocampal theta oscillations contribute to social memory processes.
Usage: Ablation of cholinergic neurons in the MS using mu-p75-SAP (IT-16, 0.2μg/0.5μl).
Related Products: mu p75-SAP (Cat. #IT-16)